PMID: 13575685Oct 1, 1958Paper

Studies on persistent infections of tissue cultures. III. Some quantitative aspects of host cell-virus interactions

The Journal of Experimental Medicine
F DEINHARDTW HENLE

Abstract

Efforts were made to obtain information on some of the quantitative aspects of host cell-virus interactions in MCN cultures persistently infected with Newcastle disease, mumps, and 6-6 viruses, and to elicit the mechanism which permits simultaneous maintenance of virus and cells for indefinite periods of time. It was shown by 4 different technics that only between 10 and less than 1 per cent of the cells yield infectious virus, depending upon the agent employed and, possibly, variations in the conditions of the cultures. No evidence was found to indicate production of non-infectious virus materials. Only the cells carrying infectious virus are capable upon transfer to uninfected cultures to transmit the infection. Cells from persistently infected cultures, which are free of infectious virus at the time of transfer, failed to liberate virus at a later time during incubation periods of up to 4 weeks. The virus-producing cells contain at any given moment not more than 1 infectious unit of virus, suggesting a linear mode of production; i.e., as soon as a virus particle is completed, it is released. Upon inoculation of MCN test tube cultures with chick embryo-adapted NDV persistent infection and interference with vesicular stomatiti...Continue Reading

References

Sep 12, 1957·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A ISAACS, J LINDENMANN
Sep 12, 1957·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A ISAACSR C VALENTINE
Oct 1, 1958·The Journal of Experimental Medicine·G HENLEW HENLE

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Citations

Jan 1, 1961·Archiv für die gesamte Virusforschung·K CANTELL
Jan 1, 1968·Archiv für die gesamte Virusforschung·E Katz, N Goldblum
Oct 1, 1958·The Journal of Experimental Medicine·G HENLEW HENLE
Dec 26, 2008·Journal of Virology·C T GarnettL R Gooding
Oct 1, 1964·Virology·A W HOLMESF DEINHARDT
Nov 1, 1964·Clinical Pediatrics·K PAUCKER

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