PMID: 14401038Oct 1, 1959Paper

Studies on persistent infections of tissue cultures. IV. Evidence for the production of an interferon in MCN cells by myxoviruses

The Journal of Experimental Medicine
W HENLEV V BERGS

Abstract

In previous reports of this series, it was shown that persistent infection of MCN cultures with certain myxoviruses rendered the cells insusceptible to superinfection by several cytopathogenic viruses. It was thought that production of an interferon might be the cause of this resistance and efforts to confirm this suggestion have been presented. Addition of ultraviolet-inactivated myxoviruses (mumps, Newcastle disease, influenza A, and Sendai) to MCN cultures for periods of 2 to 3 hours, followed by washing and refeeding of the cells, led to the subsequent release into the media of a substance which induced in fresh MCN cells a transitory resistance to infection by vesicular stomatitis virus, and prevented incomplete reproductive cycles of influenza A and Sendai viruses. Media containing this substance were free of detectable hemagglutinating activity and viral complement-fixing antigens. The substance was not neutralized by specific antiviral sera; it was not sedimentable by high speed centrifugation; it was not adsorbed onto red cells; but it was inactivated by trypsin. Thus, its properties matched those of the interferon described by Isaacs and his associates. A comparison of the extent of resistance induced in MCN cells by ...Continue Reading

References

Feb 1, 1954·Proceedings of the Society for Experimental Biology and Medicine·J S YOUNGNER
Sep 12, 1957·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A ISAACSR C VALENTINE
Oct 1, 1958·The Journal of Experimental Medicine·G HENLEW HENLE

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Citations

Dec 1, 1963·Journal of Cellular Physiology·M R HILLEMAN
Jul 1, 1965·The Journal of Pathology and Bacteriology·D S Roberts
Jan 1, 1961·Archiv für die gesamte Virusforschung·A R BEASLEYM M SIGEL
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Jan 1, 1970·Archiv für die gesamte Virusforschung·B Fauconnier
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Oct 7, 1963·Archiv für die gesamte Virusforschung·H DIDERHOLM
Mar 1, 1972·The Journal of Hygiene·R Jennings
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Aug 1, 1962·Proceedings of the National Academy of Sciences of the United States of America·H M SHEINJ D LEVINTHAL
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May 1, 1966·The Journal of Experimental Medicine·W E Rawls, J L Melnick
Feb 24, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Philip I Marcus
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Aug 11, 1962·British Medical Journal
Jan 1, 1963·Virology·K CANTELL, K PAUCKER
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Nov 1, 1964·Clinical Pediatrics·K PAUCKER
Jan 1, 1964·Acta Pathologica Et Microbiologica Scandinavica·S HERMODSSON
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Jul 9, 1960·Lancet·A ISAACS, G HITCHCOCK
Apr 12, 1963·Science·J E SMADEL

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