PMID: 8583283Dec 1, 1995Paper

Studies on photoinactivation by various phthalocyanines of a free or replicating non-enveloped virus

Journal of Photochemistry and Photobiology. B, Biology
S GaspardG H Werner

Abstract

The non-enveloped picornaviruses, which are particularly resistant to physicochemical inactivation, include the aetiological agents of poliomyelitis, hepatitis A and E and infectious common cold (rhinovirus). In this work we used human rhinovirus type 5 (RV-5) cultivated in VERO cells to study the photoinactivating effects of several phthalocyanines and naphthobenzoporphyrazines. Free RV-5 was photoinactivated by aluminium trisulphonated naphthobenzoporphyrazine at 5 x 10(-8) M concentration. This photosensitizer was also active on replicating virus when the infected VERO cells were treated with 5 x 10(-6) M concentration followed by a very short illumination period. On the other hand, the ZnPc(3-MeO-Py)4 phthalocyanine, which possesses four positive charges, does not photoinactivate free rhinovirus, but this molecule protects VERO cells against RV-5 infection when added to the cultures before virus inoculation, in the presence or absence of subsequent illumination, and may therefore be considered as an antiviral agent in itself.

References

Apr 30, 1992·Journal of Photochemistry and Photobiology. B, Biology·E Ben-HurJ Van Steveninck
Jan 1, 1994·Journal of Photochemistry and Photobiology. B, Biology·Z SmetanaZ Malik

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Citations

May 25, 2010·The Protein Journal·Qiu-Hua ZhouYan-Qing Wang
Aug 5, 2003·Antiviral Research·Andrei N VzorovDabney W Dixon
May 30, 2003·BMC Infectious Diseases·Avril R M Chen-CollinsRichard W Compans
Jun 11, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bradley L CarpenterReza A Ghiladi
Mar 22, 2008·Free Radical Biology & Medicine·Ana Jiménez-BanzoSanti Nonell
Nov 25, 2003·The British Journal of Dermatology·I M StefanakiA D Tosca
Jul 17, 2015·Biomacromolecules·Bradley L CarpenterReza A Ghiladi
Aug 10, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Arno WieheMathias O Senge

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