Studies on platelet membrane glycoproteins and platelet function during hemodialysis.

Journal of the American Society of Nephrology : JASN
J A Sloand, E M Sloand

Abstract

Hemodialysis only partially corrects the defects in platelet function associated with uremia. Platelet contact with the artificial surfaces of the dialysis filter during hemodialysis can itself cause platelet activation, degranulation, and loss of platelet membrane glycoproteins. Although the transient platelet dysfunction that occurs after platelet contact with foreign surfaces during cardiopulmonary bypass has been well characterized, there has been no such investigation of hemodialysis. In this study of hemodialysis patients, bleeding times (BT) and the response of their platelets to thrombin, ristocetin, and collagen were measured before, immediately after, and in some patients, the day after hemodialysis. In addition, membrane glycoproteins in platelets obtained at these time intervals were studied using fluorescein isothiocyanate (FITC) conjugated monoclonal antibodies (mAb) CD42b (anti-GPIb), CD41a (anti-GPIIb/IIIa), and CD62 (anti-P-selectin), with flow cytometry. BT was significantly prolonged, and response to thrombin and ristocetin was significantly decreased immediately after hemodialysis (P < 0.01). Binding of CD42b mAb to the platelet membrane was decreased in platelets obtained immediately after hemodialysis. Mos...Continue Reading

Citations

Nov 10, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J H SmitsT J Rabelink
Nov 21, 2013·The International Journal of Artificial Organs·Masa KnehtlJadranka Buturovic-Ponikvar
Aug 16, 2000·Scandinavian Journal of Clinical and Laboratory Investigation·P C BartelsM J Nubé
Jul 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Atul AggarwalDavid J Schneider
Mar 30, 2011·The International Journal of Artificial Organs·James A MilburnJulie Brittenden
Nov 5, 2003·Scandinavian Journal of Clinical and Laboratory Investigation·P C M BartelsM J Nubé
Jun 19, 2021·Journal of the American Society of Nephrology : JASN·Nishank JainJohn Arthur
Mar 11, 2004·Journal of Perinatal Medicine·Kuender D YangChia-Yo Ou
May 31, 2012·Circulation·Davide Capodanno, Dominick J Angiolillo
Jun 15, 2006·Pathophysiology of Haemostasis and Thrombosis·Miso SabovicJadranka Buturovic Ponikvar
Jun 15, 2006·Wiener klinische Wochenschrift·Walter H Hörl
Dec 1, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Danyelle Romana Alves RiosLuci Maria Santana Dusse
Jul 25, 2009·Journal of the American Society of Nephrology : JASN·Annis M MarneyNancy J Brown
Sep 4, 2009·Der Anaesthesist·C F WeberK Görlinger
Mar 13, 2010·Journal of the American College of Cardiology·Dominick J AngiolilloAntonio Fernandez-Ortiz
Aug 9, 2006·Seminars in Dialysis·Dinkar Kaw, Deepak Malhotra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.