Studies on Poly(propylene fumarate-co-caprolactone diol) Thermoset Composites towards the Development of Biodegradable Bone Fixation Devices.

International Journal of Biomaterials
M Jayabalan

Abstract

The effect of reinforcement in the cross-linked poly(propylene fumarate-co-caprolactone diol) thermoset composites based on Kevlar fibres and hydroxyapatite was studied. Cross-linked poly(propylene fumarate-co-caprolactone diol) was also studied without any reinforcement for comparison. The reinforcing fibre acts as a barrier for the curing reaction leading to longer setting time and lesser cross-link density. The fibre and HA reinforced composites have almost the same compressive strength. Nonreinforced material undergoes greater degree of swelling. Among the reinforced materials, the hydroxyapatite reinforced composite has a much higher swelling percentage than the fibre reinforced one. The studies on in vitro degradation of the cured materials reveal hydrolytic degradation in Ringer's solution and PBS medium during aging. All the three materials are found to swell initially in Ringer's solution and PBS medium during aging and then undergo gradual degradation. Compression properties of these cross-linked composites increase with aging; HA reinforced composite has the highest compressive strength and compressive modulus, whereas the aged fibre-reinforced composite has the least compressive strength and modulus.

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Citations

Aug 8, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Gaser N AbdelrasoulSzabolcs Beke
Apr 26, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Finosh Gnanaprakasam Thankam, Jayabalan Muthu
Jul 8, 2016·ACS Applied Materials & Interfaces·Ana M Díez-Pascual, Angel L Díez-Vicente
Jul 13, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Azizeh Rahmani Del BakhshayeshAzadeh Montaseri
Aug 9, 2018·Biomedical Materials·Nasim GolafshanMorteza Alehosseini

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