PMID: 8982267Dec 13, 1996Paper

Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes

Biochimica Et Biophysica Acta
Q GuoW Xin

Abstract

The comparison of the protective effects of four components of "green tea polyphenols' (GTP) - (-)-epigallocatechin gallate, EGCG; (-)-epicatechin gallate, ECG; (-)epigallocatechin, EGC; and (-)epicatechin, EC - against iron-induced lipid peroxidation in synaptosomes showed that: (1) the inhibitory effects of those compounds on TBA reactive materials from lipid peroxidation decreased in the order of EGCG > ECG > EGC > EC; (2) the scavenging effects of those compounds on lipid free radicals produced by lipid peroxidation could be classified as follows: ECG > EGCG > EC > EGC. Furthermore, we investigated the iron-chelating activity and the free radical scavenging activity of those compounds as their protective mechanisms against lipid peroxidation in synaptosomes. As for the iron-chelating activity, the ratio of EGC, EGCG, ECG or EC to iron(III) was 3:2, 2:1, 2:1 and 3:1, respectively. The hydroxyl radical (HO) scavenging activity of those compounds was investigated in a photolysis of the H2O2 system. It was found that their ability to scavenge hydroxyl radicals decreased in the order of ECG > EC > EGCG > EGC. It was also found that they could scavenge lipid free radicals in the lecithin/lipoxidase system and their scavenging act...Continue Reading

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Sep 27, 2006·Neurotoxicity Research·Yu Fu, Marcel Wing Leung Koo
Jan 31, 2008·Archives of Toxicology·Catherine McDermottJames J A Heffron
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