PMID: 5849239Oct 1, 1965Paper

Studies on rabbit lymphocytes in vitro. II. Induction of blast transformation with antisera to six IgG allotypes and summation with mixtures of antisera to different allotypes

The Journal of Experimental Medicine
P G Gell, S Sell

Abstract

Specific antisera directed against all six of the well characterised allotypic determinants of rabbit IgG (As1, 2, 3, 4, 5, and 6) are capable of inducing blast transformation and DNA synthesis when added to lymphocyte cultures obtained from donor rabbits having the appropriate IgG allotype. Mixtures of antisera directed against two different allotypic determinants induce a "summation" of transformation and DNA synthesis over and above the effect of mixtures of two antisera directed against the same allotypic determinant. This summation effect is observed regardless of whether the antisera which have been mixed are directed against allotypic determinants controlled by the same locus or by different loci. The finding that summation occurs with mixtures of two antisera directed against both the allotypic determinants of a double homozygote rabbit (As1, 6) suggests that lymphocytes from the peripheral blood may be primed to produce only one or the other of the two polypeptide chains of IgG, but not both.

References

Aug 25, 1962·Nature·S DRAYJ OUDIN
Jan 1, 1963·The Journal of Immunology : Official Journal of the American Association of Immunologists·S LESKOWITZ
Oct 1, 1964·The Journal of Experimental Medicine·P BORNSTEIN, J OUDIN

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Citations

Jul 1, 1968·Immunochemistry·S Sell, S J Hughes
Mar 1, 1968·Currents in Modern Biology·J M Vasiliev, I M Gelfand
Apr 29, 1967·Nature·S Cohen, C Milstein
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·D E Mosier, L W Coppleson
Jan 1, 1972·Preparative Biochemistry·K ZeillerK Hannig
Jan 1, 1980·Immunological Reviews·M D CooperA R Lawton
Jun 1, 1970·Journal of Cellular Physiology·J M VasilievE K Fetisova
Jun 1, 1966·Journal of Cellular Physiology·J Oudin
Mar 1, 1989·Biulleten' eksperimental'noĭ biologii i meditsiny·E A GorbatenkovaIu A Vladimirov
Jan 1, 1967·Acta Pathologica Et Microbiologica Scandinavica·G Huldt
Jan 1, 1972·Progress in Biophysics and Molecular Biology·J N Mehrishi
Sep 1, 1970·Experimental Cell Research·E KleinB Johansson
Dec 28, 1973·Science·W T ShearerC W Parker

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