Studies on rat and human thymus to demonstrate immunoreactivity of calcitonin gene-related peptide, tyrosine hydroxylase and neuropeptide Y

Journal of Anatomy
A KranzB von Gaudecker

Abstract

The peptidergic and noradrenergic innervation of rat and human thymus was investigated by immunohistochemistry at the light and electron microscopical level (avidin-biotin-complex, sucrose-phosphate-glyoxylic-acid, and immunogold techniques). The distribution of noradrenergic neural profiles, and positive immunoreactivity for calcitonin gene-related peptide (CGRP), tyrosine hydroxylase (TH) and neuropeptide Y (NPY) is described in female rats during ageing, and in human children. In the neonatal rat thymus, the arteries and septa are well supplied by fine varicose nerves. In older animals (2 wk-1 y) the number of septa and blood vessels increase and consequently also the innervation. No nerves were found in the cortex. Apart from the innervation of the septal areas, immunoreactivity for CGRP and TH was present in thymic cells. Except for the young rats (neonatal-14 d), all rats showed CGRP positivity in subcapsular/perivascular epithelial cells (type 1 cells). All rat thymuses also contained a few TH positive cells in the medulla, which could only be confirmed as epithelial cells (type 6 cells) in children. Type 1 cells in the human thymus were not CGRP positive, but as in the rat, there were similar TH positive cells in the me...Continue Reading

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Citations

Dec 13, 2001·Neurochemistry International·Daniela CavallottiCarlo Cavallotti
Feb 29, 2008·Annual Review of Immunology·Hans-Reimer Rodewald
Aug 2, 2007·Expert Opinion on Biological Therapy·Bela Bodey
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Jan 15, 2004·Microscopy Research and Technique·Jonas HannestadJosé A Vega
Mar 29, 2014·International Journal of Molecular Medicine·Fiorenzo MigniniCarlo Cavallotti

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