Abstract
Mancozeb, an ethylenebisdithiocarbamate (EBDC), has been studied for its effects on rat thyroid. Single oral administration of mancozeb at different concentrations (9600, 12,000, 15,000 and 18,750 mg kg(-1) body wt) has derived the oral LD50 value as 15,000 mg kg(-1) body wt. in male rats. Mancozeb at repeated oral doses of 500, 1000 and 1500 mg kg(-1) day(-1) for periods of 30, 90, 180 and 360 days has produced dose-dependent signs of toxicity and death of animals. The fungicide caused a significant increase in thyroid/body weight ratio and histopathological changes. Reduced levels of thyroid radioiodine ([125]I) uptake, serum protein-bound iodine (PB[125]I), thyroxine (T4) and reduced activity of thyroid peroxidase (TPO) have also been observed after exposure to mancozeb. Thus, mancozeb has been shown to produce marked structural and functional changes in thyroid of rats.
Citations
Dec 1, 2003·Environmental Toxicology and Pharmacology·Raghavendra L Ksheerasagar, Basappa B Kaliwal
Mar 30, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Güldeniz Selmanoglu, E Arzu Koçkaya
Mar 27, 2010·Omics : a Journal of Integrative Biology·Paulo J DiasIsabel Sá-Correia
Oct 20, 1998·Thyroid : Official Journal of the American Thyroid Association·F Brucker-Davis
Jul 29, 1998·Environmental Health Perspectives·P M Hurley
Jun 13, 2002·Environmental Health Perspectives·Kembra L Howdeshell
Jan 27, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marta AxelstadUlla Hass
Jun 9, 2012·Reproductive Toxicology·Pernille Rosenskjold JacobsenUlla Hass
Jan 13, 2009·Proteomics·Pedro M SantosIsabel Sá-Correia
Oct 4, 2005·Brain Research. Developmental Brain Research·Leticia Miranda-ContrerasErnesto Palacios-Prü
Feb 17, 2015·Toxicology and Applied Pharmacology·Mandana GhisariEva Cecilie Bonefeld-Jørgensen
Dec 19, 2003·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Seul Min ChoiByung Mu Lee
Jun 7, 2016·International Journal of Hygiene and Environmental Health·Élida Campos, Carmen Freire
Jan 16, 2008·Archives of Environmental Contamination and Toxicology·Rosaria SciarrilloLorenzo Varano
Oct 10, 2009·International Journal of Toxicology·J L FlippinK M Crofton
Nov 14, 2014·Expert Opinion on Drug Metabolism & Toxicology·Cécile MathieuJean-Marie Dupret
Jun 10, 2005·Ecotoxicology·Gregory J MayneBruce Hunter
Mar 4, 2005·Archives of Pharmacal Research·Ae-Hee Chung, Myoung-Yun Pyo
Jul 15, 2018·Journal of Molecular Endocrinology·Karen J OliveiraTania Maria Ortiga-Carvalho
Apr 16, 2019·Toxicology and Industrial Health·Doha YahiaMahmoud Rushdi
Apr 5, 2005·Journal of Basic and Clinical Physiology and Pharmacology·P N Baligar, B B Kaliwal
Dec 11, 2019·Toxicology and Industrial Health·Saddein EsmaielEzzatabadipour Massood
Jan 11, 2020·Frontiers in Endocrinology·Michelle LeemansJean-Baptiste Fini
Oct 9, 2020·Toxics·Noppanun NankongnabSusan Woskie
Nov 8, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Iman HassanMary E Gilbert
Jan 6, 2021·Archives of Toxicology·John R FosterStephanie Melching-Kollmuss
Aug 3, 2019·Ecotoxicology and Environmental Safety·Taghred M SaberHeba M Abdel-Ghany
Dec 19, 2020·Food Chemistry·Yuanjia ChenXiaoqun Wei
Mar 28, 2021·Environmental Research·Carmen FreireMariana F Fernández
Nov 27, 2018·Chemosphere·Tanandra BernieriLuciano Basso da Silva
Jan 5, 2014·Chemical Research in Toxicology·Katie B PaulSteven O Simmons
Nov 11, 2021·The Science of the Total Environment·Andrea Corrales VargasBerna van Wendel de Joode