Studies on resistance of Schistosoma to praziquantel XVII Biological characteristics of praziquantel-resistant isolates of Schistosoma japonicum in mice

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control
Qian KeDai Jian-Rong

Abstract

To investigate the biological characteristics of the praziquantel-resistant isolate of Schistosoma japonicum in mice, so as to explore the pathogenicity to definitive hosts and transmission intensity of the praziquantel-resistant isolate of S. japonicum. Mice were infected with the cercariae released from two praziquantel-resistant isolates and two praziquantel-susceptible isolates of S. japonicum. The mouse-Oncomelania hupensis snail-mouse cycle was established and maintained in the laboratory. The prepatent period of parasite eggs, egg production, egg distribution in mice, parasite susceptibility to mice and egg size were investigated in each parasite isolate. The prepatent period of parasite eggs, egg counts in mouse feces, adult worms recovered from each mouse, egg counts in mouse tissues, egg counts in the mouse liver, and egg counts in intestine tissues were 36.1 d and 36.8 d (t = 0.907, P = 0.372), 14.6 / 100 mg and 21.2 / 100 mg (t = 2.946, P = 0.007), 20.5 and 25.1 worms per mouse (t = 2.128, P = 0.042), 31 303 and 38 594 per paired adult worm (t = 2.185, P = 0.04), 14 810 and 19 715 per paired adult worm (t = 2.934, P = 0.007), and 16 493 and 18 879 per paired adult worm (t = 1.044, P = 0.309) in the mice infected wit...Continue Reading

Citations

Dec 24, 2018·Tropical Medicine and Infectious Disease·Robert Bergquist, Hala Elmorshedy

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