Studies on selectin-carbohydrate interactions

Advances in Experimental Medicine and Biology
G S JacobC N Steininger

Abstract

Recruitment of neutrophils to sites of inflammation is now believed to occur through an initial rolling interaction at the luminal surface of activated endothelium and is mediated by a class of mammalian lectins referred to as the selectins. Selectins recognize carbohydrate determinants on co-receptors. It is generally believed that many selectin molecules must bind to many carbohydrate receptor molecules i.e. multivalent binding, to enable sufficient binding strength to elicit the rolling response between the neutrophil and the endothelial cell. One of the approaches to the generation of more potent molecular antagonists of the selectin-mediated cell-cell interaction is to mimic the multivalent interaction in a single compound. Recent experiments utilising conjugated forms of sialyl Lewisx-BSA have explored this feasibility (Welply et al., 1994). In that study, monovalent sLex (sialic acid alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc), the minimum binding determinant for E-selectin, as well as monovalent sialyllactosamine (sialic acid alpha 2-3Gal beta 1-4GlcNAc), a non-binding structure, and the corresponding multivalent BSA-conjugated forms were tested for their ability to inhibit binding of HL-60 cells to immobilised E-select...Continue Reading

Citations

Jun 13, 2012·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Koji Higai, Kojiro Matsumoto
Sep 3, 2003·The Journal of Biological Chemistry·Huey-Chun HuangHua-Lin Wu
Apr 14, 2016·Molecular & Cellular Proteomics : MCP·Shou-Ling XuRobert J Chalkley
Jan 15, 2003·The Journal of Biological Chemistry·Chantal C M AppeldoornErik A L Biessen
Jun 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Igor TvaroškaJaroslav Koča
Feb 14, 2002·Chemical Reviews·Joseph J Lundquist, Eric J Toone
Feb 6, 2015·Analytical Chemistry·Katalin F MedzihradszkyRobert J Chalkley

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