PMID: 12781352Jun 5, 2003Paper

Studies on serotonergic markers in the human hippocampus: changes in subjects with bipolar disorder

Journal of Affective Disorders
Brian DeanDavid Copolov

Abstract

Various studies suggest the hippocampus and serotonergic systems are important in the pathology of bipolar disorder (BD). We therefore measured hippocampal serotonergic markers in post-mortem tissue from BD and control subjects. The density and affinity of [3H]citalopram binding to the serotonin transporter (SERT), as well as the density of the 5HT(2A), 5HT(1A), 5HT(1D) and 5HT(1F) receptors were measured. The density of SERT and 5HT receptors was no different in BD. There was a significant decrease in the affinity of [3H]citalopram binding to SERT in the stratum lacunosum-moleculare (S(lac)) in BD (K(d) mean+/-S.E.M.=4.3+/-0.8 vs. 1.9+/-0.3 nM). This study was completed using relatively small cohorts. There are no generalised changes in hippocampal serotonergic markers in the hippocampus from subjects with BD. There is a decreased affinity of radioligand binding to S(lac) SERT in subjects with BD.

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Citations

Mar 30, 2010·Der Nervenarzt·S HaackM Bauer
Feb 14, 2013·Schizophrenia Research·Brian Dean
Dec 1, 2007·The International Journal of Neuropsychopharmacology·Antonio DragoAlessandro Serretti
Mar 24, 2010·The Australian and New Zealand Journal of Psychiatry·Maxwell R Bennett
Feb 14, 2004·The Australian and New Zealand Journal of Psychiatry·Brian Dean

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