PMID: 8607563Oct 1, 1995Paper

Studies on shared antigenic/allergenic components among fungi

Allergy
J VermaS V Gangal

Abstract

Fungal allergens have been found to be one of the most prevalent aeroallergens in India. Knowledge of shared/unique components among different fungi is necessary for proper diagnosis and treatment of patients allergic to fungi. In the present study, crude extracts (CE) of 11 common fungi (Alternaria alternata, Aspergillus flavus, Asp. fumigatus, Asp. niger, Asp. tamarii, Asp. versicolor, Cladosporium herbarum, Curvularia lunata, Mucor hiemalis, Penicillium citrinum, and Fusarium solani) were characterized by isoelectric focusing (IEF), SDS-PAGE, and immunoblot. On IEF (pI 3-9), the number of protein bands was found to be greatest (46) in M. hiemalis extract. SDS-PAGE exhibited a varied number of bands, generally 18-40, with mol. mass ranging from 14 to 100 kDa. IgG-specific immunoprint using rabbit anti-F. solani CF antibodies demonstrated a mol. mass distribution of shared antigenic proteins of 14-100 kDa in most of the fungi. Shared allergenicity was observed in a number of allergenic proteins in fungal extracts with mol. mass ranging between 14 and 70 kDa on IgE-specific immunoblot using pooled sera of patients allergic to Fusarium. A 45-kDa protein was found to be common among these fungi on immunoblot with patients as well...Continue Reading

References

Feb 1, 1977·Infection and Immunity·V P Kurup, J N Fink
Jan 1, 1979·International Archives of Allergy and Applied Immunology·H M VijayI L Bernstein
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jul 1, 1990·The Journal of Allergy and Clinical Immunology·A De ZubiriaS B Lehrer
Apr 1, 1987·The Journal of Allergy and Clinical Immunology·R D TeeA J Taylor
Jul 1, 1985·Clinical Reviews in Allergy·H A Burge
Mar 1, 1981·The Journal of Allergy and Clinical Immunology·R M KarrJ E Salvaggio
Dec 1, 1982·The Journal of Allergy and Clinical Immunology·M K AgarwalJ W Yunginger
Nov 1, 1981·The Journal of Allergy and Clinical Immunology·J Salvaggio, L Aukrust
Jan 1, 1994·International Archives of Allergy and Immunology·J Verma, S V Gangal

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Citations

Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J VermaN Arora
Mar 28, 2012·Arhiv za higijenu rada i toksikologiju·Ali Reza KhosraviMohammad Hossein Yadegari

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