Studies on the absorptive defect for triglyceride in abetalipoproteinemia

The Journal of Clinical Investigation
P WaysC E Rubin

Abstract

The nature of the gastrointestinal absorptive defect for triglyceride in three subjects with abetalipoproteinemia has been investigated by studying peroral biopsies of the gastrointestinal mucosa. The following conclusions were reached.1) In confirmation of other studies, the abnormal vacuoles within the duodenal absorptive cells of these individuals were lipophilic.2) On chemical analysis there was significantly more mucosal lipid than found in normal fasting specimens, and almost the entire increase was due to triglyceride.3) This excess mucosal lipid was reduced by a low fat diet, but even after 34 days on such a diet there was still an excess of lipophilic material near the villus tip and increased quantities of total lipid and triglyceride when compared with material from normal subjects similarly treated.4) Although there are demonstrable qualitative changes in mucosal and plasma lipids after an acute fat load, they are not quantitatively as great as in normal individuals. Fat balance studies and the qualitative changes in plasma and tissue lipids that do occur after more extended periods on different types of dietary fat do indicate that a considerable percentage of the dietary fat is assimilated. The route by which it i...Continue Reading

References

Sep 1, 1966·The Journal of Clinical Investigation·D R SaundersC E Rubin
Aug 1, 1963·The Journal of Clinical Investigation·P WAYSD J HANAHAN
Jul 1, 1964·The Journal of Clinical Investigation·E R SIMON, P WAYS
Jun 1, 1965·The Journal of Clinical Investigation·J CROWLEYJ W JONES

❮ Previous
Next ❯

Citations

Jul 3, 2007·Histochemistry and Cell Biology·S GuilmeauM E Samson-Bouma
Oct 8, 1999·The Biochemical Journal·H R JungM K Hellerstein
Aug 1, 1968·Archives of Disease in Childhood·J K Lloyd
Apr 1, 1969·Archives of Disease in Childhood·F C LeylandO H Wolff
Jul 1, 1967·The Journal of Clinical Investigation·J W Jones, P Ways
May 1, 1981·The Journal of Clinical Investigation·M J MalloyK B Dalal
Apr 1, 1991·European Journal of Pediatrics·M KacińskiJ Sznajd
Apr 1, 1977·Experimental and Molecular Pathology·S M SabesinP R Holt
Aug 15, 2000·Annual Review of Nutrition·N Berriot-VaroqueauxJ R Wetterau
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M I AviganJ H Hoofnagle
Apr 1, 1980·British Journal of Haematology·P FonduI Mandelbaum
Dec 1, 1970·The British Journal of Nutrition·J Kelleher, M S Losowsky
May 22, 1988·Biochimica Et Biophysica Acta·D M Lee, S Singh
Jan 21, 1969·Biochimica Et Biophysica Acta·H J Kayden, M Medick
Mar 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·J BoonE Schretlen
Nov 1, 1972·The Journal of Pediatrics·M E Ament

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Clinical Investigation
R I LevyL Laster
Acta paediatrica Scandinavica
M YssingS Jarnum
The Journal of Pediatrics
P J Santiago-BorreroE Horta
Acta paediatrica Scandinavica
K LaunialaJ K Visakorpi
© 2021 Meta ULC. All rights reserved