Studies on the alkaloid composition of the Hawaiian Baby Woodrose Argyreia nervosa, a common legal high

Forensic Science International : Synergy
Alexander PaulkeStefan W Toennes

Abstract

Seeds from the Hawaiian Baby Woodrose Argyreia nervosa of different origin and labelling and with allegedly high levels of ergot alkaloids were analysed using high performance liquid chromatography-high resolution mass spectrometry (HPLC-HRMS/MS) technique. Lysergic acid amide (LSA), ergometrine, lysergol/elymoclavine/setoclavine, chanoclavine, lysergic acid and their respective stereoisomers were identified as well as penniclavine and lysergic acid α-hydroxyethylamide. In addition, methylergometrine, methysergide, and lysergylalanine were detected, some high molecular weight ergot alkaloid derivatives and hydroxyalanine derived ergopeptide fragments were detected indicating the presence of ergopeptides in the seeds. The results of the study demonstrate that the content of ergot alkaloids in Argyreia nervosa seeds depends on the quality of the material. For a consumer the quality of the seeds is unforeseeable. For the toxicological expert it is essential to investigate not only the identity of such a confiscated seed material, but also the various ergot alkaloid constituents to assess the hazardous nature and the toxic potential of the material.

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Dec 19, 2009·Forensic Science International : Synergy·Helene Bendstrup KlinkeRasmus Dahl-Sørensen
Aug 2, 2011·Forensic Science International : Synergy·Christian KremerStefan W Toennes
Jun 15, 2012·Analytical and Bioanalytical Chemistry·Alexander PaulkeStefan W Toennes
Jul 19, 2014·Forensic Science International : Synergy·Alexander PaulkeStefan W Toennes

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Citations

Feb 14, 2016·Analytical and Bioanalytical Chemistry·Julia NowakPaweł Kościelniak
Nov 11, 2019·Journal of Pharmaceutical and Biomedical Analysis·Alfredo Fabrizio Lo FaroFrancesco Paolo Busardò
Mar 5, 2021·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Esther SobanskiMichael Huss
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joana GonçalvesAna Paula Duarte

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