Studies on the allostimulatory function of dendritic cells from HCV-HIV-1 co-infected patients

Cell Research
Justin StebbingBrian Gazzard

Abstract

There is increasing recognition of the potential morbidity and mortality associated with HIV-1 and hepatitis C (HCV) co-infection. HIV appears to adversely affect HCV disease while the reciprocal effect of HCV on HIV remains controversial. We therefore studied the effect of co-infection on dendritic cell function versus HIV infection alone, as previous work has shown that HCV impairs dendritic cell (DC) function. HIV-1 positive individuals with HCV were matched for CD4 count, HIV-1 RNA viral load and therapy, to HIV-1 positive patients without HCV. Monocyte-derived DC were generated and mixed leukocyte reactions were performed. We assessed allostimulatory capacity with and without administration of exogenous Th1 cytokines, using thymidine uptake and cell division analyses with the vital dye CFSE. We found that monocyte-derived DC from co-infected individuals showed no significant differences in allostimulatory capacity to ex vivo generated DC from HIV-1 infected individuals without HCV. Unlike the situation with HCV infection alone, this impairment was not reversed by increasing concentrations of either interleukin-2 or -12. Monocyte-derived DC from HIV-1 and HCV co-infected individuals have a similar allostimulatory capacity t...Continue Reading

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Citations

Jun 14, 2005·Current Opinion in Immunology·Maria A SuniHolden T Maecker
Aug 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Justin StebbingBrian Gazzard
Feb 23, 2010·Journal of Translational Medicine·Luigi BuonaguroFranco M Buonaguro
Jan 24, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Lynn AverillNitin J Karandikar
Mar 10, 2005·International Journal of Cancer. Journal International Du Cancer·Laura WatersMark Bower
Jul 20, 2007·Clinical and Vaccine Immunology : CVI·Zheng FanCharles R Rinaldo

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