Studies on the analgesic and anti-inflammatory effects of Sideritis candicans Ait. var. eriocephala Webb aerial part

Journal of Ethnopharmacology
Margarita Hernández-PérezR Rabanal

Abstract

Different extracts and fractions from Sideritis candicans Ait. var. eriocephala Webb aerial part were investigated for their analgesic, anti-inflammatory and antimicrobial activities in mice. Results indicated that the extracts assayed showed anti-nociceptive activities because they were able to reduce the nociceptive response to chemical pain stimuli, such as in the acetic acid-induced writhing test. Moreover the extracts also possessed anti-inflammatory activity against carrageenan-induced paw oedema and TPA-induced ear oedema, being the chloroform fraction the most active. Further fractionation and analysis of this fraction revealed that the analgesic and anti-inflammatory activities found could be related in part to the presence of phytosterols, alpha and beta amyrin triterpenic derivatives and ent-kaurene type diterpenes in this species, since some of these compounds are endowed with these activities.

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Citations

Jun 14, 2005·Phytochemistry·Hanae GhoumariOswaldo Socorro
Apr 17, 2007·Journal of Ethnobiology and Ethnomedicine·Silvia AkerretaMaría Isabel Calvo
Jul 31, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Elif Odabaş KöseMustafa Yavuz
Jul 9, 2005·Journal of Ethnopharmacology·Andrea PieroniCenk Durmuşkahya
Mar 23, 2011·Journal of Ethnopharmacology·E González-BurgosM P Gómez-Serranillos

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