Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract in Mouse Model

Evidence-based Complementary and Alternative Medicine : ECAM
Jingjing SongLesheng Teng

Abstract

Cordyceps militaris has been used extensively as a crude drug and a folk tonic food in East Asia due to its various pharmacological activities. Our study aims to investigate the effect of Cordyceps militaris fruit body extract (CM) on antifatigue in mouse model. Two week CM administration significantly delayed fatigue phenomenon which is confirmed via rotating rod test, forced swimming test and forced running test. Compared to nontreated mouse, CM administration increased ATP levels and antioxidative enzymes activity and reduced the levels of lactic acid, lactic dehydrogenase, malondialdehyde, and reactive oxygen species. Further data suggests that CM-induced fatigue recovery is mainly through activating 5'-AMP-activated protein kinase (AMPK) and protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways and regulating serum hormone level. Moreover, CM-enhanced the phosphorylation of AMPK contributes to its antioxidant effect. Our data provides experimental evidence in supporting clinical use of CM as an effective agent against fatigue.

References

Aug 31, 1982·Biochemical and Biophysical Research Communications·K J DaviesL Packer
Jan 1, 1997·Medicine and Science in Sports and Exercise·J M Davis, S P Bailey
Aug 28, 1998·Science·D R Green, J C Reed
Mar 26, 1999·Sports Medicine·D C Nieman, B K Pedersen
Jul 20, 1999·Clinics in Sports Medicine·S K Powers, K Hamilton
Jan 5, 2002·Bioscience, Biotechnology, and Biochemistry·K M KimH J Suh
Feb 20, 2004·Journal of Sports Sciences·Scott K PowersKaryn L Hamilton
Dec 6, 2005·Biological & Pharmaceutical Bulletin·Sundaramahalingam ManikandanRathinasamy Sheela Devi
Dec 16, 2005·The Journal of Pharmacy and Pharmacology·T B Ng, H X Wang
Feb 14, 2006·Cell·Stephan WullschlegerMichael N Hall
Feb 14, 2006·International Journal of Sports Medicine·M DékányJ Pucsok
Apr 20, 2006·American Journal of Physiology. Endocrinology and Metabolism·Anna-Maree AxellJeffrey D Zajac
Mar 3, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anne FredstedTorben Clausen
Feb 9, 2008·European Journal of Clinical Investigation·K P SkenderiG P Chrousos
Jun 6, 2009·Psychoneuroendocrinology·Meena KumariMika Kivimaki
Dec 26, 2009·The Chinese Journal of Physiology·Shih-Chung HuangChiang-Ting Chien
Jul 24, 2010·Fitoterapia·Shonkor Kumar DasMikio Sakakibara
Oct 6, 2010·Journal of Ethnopharmacology·Lin-Zhang HuangLu-Ping Qin
May 7, 2011·Reviews in Cardiovascular Medicine·Adam Whaley-ConnellJames R Sowers
Nov 15, 2011·European Journal of Applied Physiology·Tatiane Oliveira BarretoEtel Rocha-Vieira
Jun 12, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G C BogdanisM Maridaki
Jan 21, 2014·Journal of Biochemistry·Miribane Dërmaku-SopjaniMentor Sopjani
Mar 4, 2014·Physiology·D Grahame Hardie, Michael L J Ashford
Jul 22, 2014·Nutrients·Wen-Ching HuangChi-Chang Huang
Oct 30, 2014·Molecular Medicine Reports·Yuan DongLirong Teng

❮ Previous
Next ❯

Citations

Mar 31, 2018·Experimental and Therapeutic Medicine·Xue JiangDi Wang
Sep 12, 2017·BioMed Research International·Ping GengJian-Yong Wu
May 11, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Xuhua YuYinji Xu
Feb 26, 2021·Frontiers in Pharmacology·Gitishree DasJayanta Kumar Patra
Jun 9, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Chengle YinZhi-Ling Yu

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
electrophoresis
MDA

Software Mentioned

Quantity One
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.