Studies on the antioxidant properties of some phytoestrogens

Luminescence : the Journal of Biological and Chemical Luminescence
Aleksandra KładnaHassan Y Aboul-Enein

Abstract

Isoflavones genistein and daidzein are nonsteroidal phytoestrogens occurring mainly in soybean foods. These phytoestrogens possess estrogenic properties and show a variety of health benefits as anti-inflammatory agents. However, the mechanism of their action has not been identified in detail. The aim of this study is to characterize the antioxidant powers of genistein, daidzein and daidzein metabolite-equol through their activities to scavenge superoxide anion radical (O(•) 2 (-) ), hydroxyl radical (HO(•) ), 2,2-diphenyl-1-picrylhydrazyl radical (DPPH(•) ) and hydrogen peroxide (H2 O2 ) using chemiluminescence and spectrophotometry techniques. Potassium superoxide in dimethyl sulphoxide (DMSO) and 18-crown-6 ether were used as a source of O(•) 2 (-) . Hydroxyl radicals were produced using the Fenton reaction. In free radical assays, genistein had the IC50 values (an amount of antioxidant concentration required to decrease the initial radical concentration by 50%) 0.391 ± 0.012 mM for O(•) 2 (-) , 0.621 ± 0.028 mM for HO(•) and 1.89 ± 0.16 mM for DPPH(•) . The IC50 values for daidzein for these free radicals were 1.924 ± 0.011 mM, 0.702 ± 0.012 mM and 2.81 ± 0.03 mM, respectively. Equol was the most active the free radical scav...Continue Reading

References

Jul 1, 1979·Physiological Reviews·B ChanceA Boveris
Jul 8, 1975·Biochimica Et Biophysica Acta·C L Greenstock, R W Miller
Jan 1, 1984·Methods in Enzymology·J S ValentineD T Sawyer
Oct 1, 1993·Free Radical Biology & Medicine·S GoldsteinG Czapski
Jan 1, 1996·Free Radical Biology & Medicine·S A van AckerA Bast
Jan 1, 1996·Free Radical Biology & Medicine·C A Rice-EvansG Paganga
Jun 6, 2000·Mutation Research·J Termini
Aug 5, 2000·Journal of Natural Products·P G Pietta
May 29, 2002·Phytochemistry·Richard A Dixon, Daneel Ferreira
Jul 18, 2002·The Journal of Nutritional Biochemistry·Hong Zhong WangRong Qing Zhang
Jan 14, 2005·Molecular and Cellular Biochemistry·Marian ValkoJoshua Telser
May 26, 2005·Bioscience, Biotechnology, and Biochemistry·Yu-Chi ChenAkira Hirota
Aug 22, 2006·Phytochemistry·Ameha SeyoumFathy Kandeel El-Fiky
Jul 13, 2007·Bioorganic & Medicinal Chemistry·Ana GomesJosé L F C Lima
Jan 15, 2007·Talanta·D VillañoM C García-Parrilla
Apr 8, 2010·Free Radical Research·Geou-Yarh Liou, Peter Storz
Aug 17, 2010·Bioorganic & Medicinal Chemistry·Clementina M M SantosEduarda Fernandes
Sep 15, 2010·Molecular Aspects of Medicine·Richard C M Siow, Giovanni E Mann
Sep 16, 2010·Free Radical Biology & Medicine·Simone ReuterBharat B Aggarwal
Jan 13, 2011·Angewandte Chemie·Stéphane QuideauLaurent Pouységu
Mar 4, 2011·Luminescence : the Journal of Biological and Chemical Luminescence·Irena KrukHassan Y Aboul-Enein
Dec 23, 2011·Current Pharmaceutical Design·Jose VinaConsuelo Borras
Dec 27, 2011·Bioorganic & Medicinal Chemistry·Jane GreeffSandra van Dyk
Jul 11, 2012·Journal of Cellular Physiology·Lei-Guo MingCory J Xian
Aug 3, 2012·The Journal of Physical Chemistry. a·Sandipan Chakraborty, P K Biswas
Nov 24, 2012·Molecular Nutrition & Food Research·Ivonne M C M RietjensJochem Louisse
Feb 19, 2013·Brain Research·Nathalie SumienMichael J Forster
Jun 21, 2013·Luminescence : the Journal of Biological and Chemical Luminescence·Xiaoqi TaoJianzhong Shen
Apr 16, 2014·Luminescence : the Journal of Biological and Chemical Luminescence·Paweł BerczyńskiRahmiye Ertan
Aug 28, 2014·European Journal of Pharmacology·Alexander V Sirotkin, Abdel Halim Harrath

❮ Previous
Next ❯

Citations

Jun 5, 2019·Critical Reviews in Food Science and Nutrition·Ángela PeiroténJosé M Landete
Feb 21, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·C P TeixeiraM J Simões
Nov 8, 2016·Animal : an International Journal of Animal Bioscience·S MattioliC Castellini
Oct 21, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·María D Navarro-HortalJosé L Quiles
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Justyna GorzkiewiczIzabela Sadowska-Bartosz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Luminescence : the Journal of Biological and Chemical Luminescence
Aleksandra KładnaR Ertan
Luminescence : the Journal of Biological and Chemical Luminescence
Paweł BerczyńskiHassan Y Aboul-Enein
Luminescence : the Journal of Biological and Chemical Luminescence
Irena KrukHassan Y Aboul-Enein
© 2022 Meta ULC. All rights reserved