PMID: 7336761Nov 1, 1981Paper

Studies on the biliary excretion and metabolites of hexachlorobenzene in the rat

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
K IngebrigtsenM Førde

Abstract

1. The biliary excretion of metabolites of hexachlorobenzene (HCB) was studied in rats dosed intragastrically with 14C-HCB. Approx. 80% dose was absorbed from the gastrointestinal tract. An average of 3.6% dose was recovered in the bile of bile-duct-cannulated rats in 48 h. 2. By g.l.c.-mass spectrometry, 2.0 and 1.8% of the 14C excreted in the 24 h bile was shown to be due to unchanged HCB and pentachlorobenzene (PCB), respectively. The major metabolite pentachlorophenol (PCP) accounted for 24.2%. 3. Sulphur-containing metabolites were not identified. However, the hepatic GSH concn. decreased by 50% within 24 h following oral administration of HCB (200 mg/kg).

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Nov 1, 1979·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J U Skaare, E Solheim
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Citations

Apr 1, 1985·Bulletin of Environmental Contamination and Toxicology·W SchülerD Manz
Sep 15, 1984·Toxicology and Applied Pharmacology·E Scheufler, K Rozman
Jan 1, 1986·General Pharmacology·K IngebrigtsenM Førde
Oct 1, 1993·Risk Analysis : an Official Publication of the Society for Risk Analysis·W L RothA G Wilson
Feb 1, 1992·Toxicology and Applied Pharmacology·M D'Amour, M Charbonneau
Jun 1, 1997·Human & Experimental Toxicology·M L QueirozH Toledo
Oct 30, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ronald J JandacekPatrick Tso
Nov 13, 2017·Pharmacological Reports : PR·Beata Starek-ŚwiechowiczAndrzej Starek
Sep 15, 1998·Immunopharmacology and Immunotoxicology·M L QueirozJ P Silveira
Apr 1, 1983·Acta Pharmacologica Et Toxicologica·K Ingebrigtsen, I Nafstad

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