Studies on the centrally mediated hypotensive activity of guanabenz

European Journal of Pharmacology
T Baum, A T Shropshire

Abstract

Prior studies demonstrated that guanabenz reduces systemic blood pressure by inhibiting central sympathetic outflow as well as by adrenergic neuron blockade. Potential mechanisms responsible for the reduction of efferent sympathetic activity were examined in the present series. Guanabenz failed to modify carotid sinus nerve activity in a perfused sinus preparation. It reduced sympathetic outflow, heart rate and blood pressure in debuffered cats indicating that its actions are not mediated primarily by baroreceptor mechanisms. alpha-Adrenergic blockade greatly attenuated the response suggesting that the central sympathoinhibitory effect of guanabenz results from alpha-adrenergic receptor activation. Only a high dose of the compound attenuated the increase in sympathetic nerve activity produced by stimulation of the posterior hypothalamus. These experiments lead to the overall conclusion that guanabenz acts primarily at sites which regulate the basal level of sympathetic outflow.

References

May 1, 1975·European Journal of Pharmacology·T Baum, A T Shropshire
Feb 1, 1973·The Journal of Pharmacy and Pharmacology·P A Van Zwieten
May 17, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·A PhilippuG Roensberg
Oct 1, 1973·Journal of Clinical Pharmacology·D T Nash
Oct 1, 1972·European Journal of Pharmacology·H Aars
Oct 1, 1972·Circulation Research·C L PelletierJ T Shepherd
Dec 1, 1954·The Journal of Comparative Neurology·C H SAWYERJ D GREEN

Citations

Feb 1, 1979·Journal of Clinical Pharmacology·C V RamC E Gomez-Sanchez
Apr 1, 1991·Journal of Clinical Pharmacology·M A BaezD J Weidler
Apr 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·J S GutkindM A Enero
May 20, 1983·European Journal of Pharmacology·M C Koss
Sep 4, 1999·Clinical and Experimental Pharmacology & Physiology·P J Young, J H Miller
Apr 1, 1978·Postgraduate Medical Journal·E S Johnson
Feb 14, 2016·Lancet Neurology·Sharon W Way, Brian Popko
Dec 24, 2015·Frontiers in Neurology·Danielle E HarlowAugusto A Miravalle
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·J S Gutkind, M A Enero
Aug 26, 2015·Antimicrobial Agents and Chemotherapy·Imaan BenmerzougaWilliam J Sullivan
Sep 29, 2012·International Dental Journal·Rodrigo De NardoJørgen Slots
May 23, 2014·Cellular Microbiology·William M Nauseef
Aug 26, 2016·Immunological Reviews·Kelly L Singel, Brahm H Segal
Jan 1, 1985·Drug Intelligence & Clinical Pharmacy·J T Mulry
Jan 1, 1982·The Journal of International Medical Research·B R WalkerB A Levey
Apr 1, 1981·Journal of Clinical Pharmacology·O B HollandC E Gomez-Sanchez
Jan 1, 1982·The Journal of International Medical Research·B R WalkerM W Deitch
Nov 11, 2020·Scientific Reports·Kaitlyn Koenig Thompson, Stella E Tsirka
Sep 27, 2020·Experimental Parasitology·Geetansh SharmaUjjala Ghoshal
Jan 8, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kuo-Hao HoKu-Chung Chen

Related Concepts

Adrenergic alpha-Antagonists
Metazoa
Diastolic Blood Pressure
Structure of Carotid Sinus
Felis catus
Denervation
Depression, Chemical
Electric Stimulation Technique
Ganglia, Spinal
Wytensin

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Incretins

Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.