PMID: 21823451Aug 10, 2011

Studies on the chemical constituents of Coleus forskohlii transplanted in Tongcheng and their antitumor activity

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
De-Hong HuangHe-zhen Wu


To study the chemical constituents of Coleus forskohlii. Isolation and purification were carried out by silica gel column chromatographic and Toyopearl HW-40F. Compounds were identified and elucidated by spectral and chemical methods. Seven compounds were obtained from ethyl acetate extract fraction. Their structures were identified as lupeol (1), oleanolic acid (2), uvalo(3), beta-sitosterol (4), colonic acid (5), demethylcryptojaponol (6), coleolic acid (7). Compounds 1, 2, 6, 7 showed obviously antitumor activity. Compound 1 and 3 are isolated from the genus for the first time. Moreover, compound 1 is firstly found to have antitumor activity from the plants.

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