PMID: 6160877Jun 13, 1980Paper

Studies on the complex between human alpha 2-macroglobulin and Crotalus adamanteus proteinase II. Release of active proteinase from the complex

Biochimica Et Biophysica Acta
L F Kress, T Kurecki

Abstract

Proteinase II from Crotalus adamanteus venom formed a complex with human alpha 2-macroglobulin in which approx. 1.7 mol of enzyme were bound per mol inhibitor. The complex did not enzymatically inactivate human alpha 1 proteinase inhibitor. However, active proteinase II was released from the complex in the presence of a high molecular weight proteinase fraction from C. adamanteus venom. The alpha 2-macroglobulin-proteinase II complex was also unstable during incubation in serum, and the enzyme released from the complex caused inactivation of serum proteinase inhibitors. The results indicate conditions under which venom proteinases can be dissociated from their complexes with alpha 2-macroglobulin and thus remain functional in the presence of molar excesses of inhibitor.

References

Oct 1, 1975·British Journal of Haematology·M J Gallimore
Aug 1, 1976·The Biochemical Journal·E Vahtera, U Hamberg
Jan 1, 1976·Methods in Enzymology·P C Harpel
Jan 23, 1975·Biochimica Et Biophysica Acta·H RinderknechtM C Geokas
Jul 28, 1978·Biochemical and Biophysical Research Communications·L F Kress, E A Paroski
Jan 1, 1976·Methods in Enzymology·S IwanagaT Suzuki
Jul 1, 1972·The Journal of Clinical Investigation·D J McConnell
Jul 1, 1970·British Journal of Haematology·W R Pitney, E Regoeczi
Jan 25, 1973·Biochimica Et Biophysica Acta·H Rinderknecht, M C Geokas
Oct 1, 1966·Clinica Chimica Acta; International Journal of Clinical Chemistry·P O Ganrot
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C D Rock, J A Zeevaart
May 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Christoph ZechnerHeinz Koeppl

❮ Previous
Next ❯

Citations

Jan 1, 1981·Toxicon : Official Journal of the International Society on Toxinology·L F Kress, J J Catanese
Jan 1, 1987·Toxicon : Official Journal of the International Society on Toxinology·C A de Wit, B R Weström
Mar 5, 1999·Critical Reviews in Toxicology·R HatiK K Bhattacharyya
Sep 25, 2012·Toxicon : Official Journal of the International Society on Toxinology·Francis S Markland, Stephen Swenson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Toxicon : Official Journal of the International Society on Toxinology
R M Kini
Toxicon : Official Journal of the International Society on Toxinology
S G Anderson, C L Ownby
Pharmacology & Therapeutics
J B Bjarnason, J W Fox
© 2021 Meta ULC. All rights reserved