Studies on the conformation and interactions of elastin: nuclear magnetic resonance of the polyhexapeptide.

International Journal of Peptide and Protein Research
D W UrryL W Mitchell

Abstract

Synthesis, proton magnetic resonance and carbon-13 magnetic resonance characterizations, including complete assignments, are reported for the polyhexapeptide of elastin, HCO-Val(Ala1-Pro2-Gly3-Val4-Gly5-Val6)18-OMe. Temperature dependence of peptide NH chemical shifts and solvent dependence of peptide C-O chemical shifts have been determined in several solvents and have been interpreted in terms of four hydrogen bonded rings for each repeat of the polyhexapeptide. The more stable hydrogen bonded ring is a beta-turn involving Ala1C-O--HN-Val4. More dynamic hydrogen bonds are an 11-atom hydrogen bonded ring Gly3NH--O-C Gly5, a 7-atom hydrogen bonded ring (a gamma-turn) Gly3 C-O--NH-Gly5, and a 23-atom hydrogen bonded ring Val6inH--O-C Val6(i+1). This set of hydrogen bonds results in a right-handed beta-spiral structure with slightly more than two repeats (approximately 2.2) per turn of spiral. The beta-spiral structure is briefly discussed relative to data on the elastic fiber.

References

Jul 12, 1973·Biochimica Et Biophysica Acta·B A CoxD W Urry
Jan 1, 1974·Perspectives in Biology and Medicine·D W Urry
Dec 18, 1974·Biochimica Et Biophysica Acta·D W UrryM Jacobs
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·D W Urry
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May 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·D W UrryR Walter
May 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·D W Urry, R Walter
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Jul 23, 1969·Biochemical and Biophysical Research Communications·M Ohnishi, D W Urry

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Citations

Jan 1, 1985·International Journal of Peptide and Protein Research·M VeredA Gertler
Jan 1, 1980·CRC Critical Reviews in Biochemistry·C Toniolo
Mar 1, 1983·Ultrastructural Pathology·D W Urry
Jun 3, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Makiko NakamuraEiry Kobatake
Dec 1, 1976·Biopolymers·K Okamoto, D W Urry
May 11, 2010·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Lisa D MuiznieksFred W Keeley
Jan 1, 1993·Upsala Journal of Medical Sciences·R TarnawskiM Drózdz
Nov 13, 2014·Chemistry : a European Journal·Jennifer L HickeyLeonard G Luyt
May 26, 1999·International Journal of Biological Macromolecules·C Y HayashiR V Lewis
Apr 10, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Yinan LinDavid L Kaplan

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