Studies on the correlation between blood cholinesterase inhibition and 'target tissue' inhibition in pesticide-treated rats

Toxicology
S PadillaP J Bushnell

Abstract

Inhibition of cholinesterase activity in the blood has been proposed as an index of ChE activity in tissues targeted by ChE-inhibiting pesticides, including the muscle end-plate region and the central nervous system (CNS). While opinions vary regarding the utility of blood ChE activity in predicting ChE activity in the target tissues, there appear to be no comprehensive studies designed to assess this possible correlation in a time- and dose-dependent manner. We undertook this type of study by administering a single dose of an organophosphate, chlorpyrifos (0, 30, 60 or 125 mg/kg in corn oil, s.c.) to rats and then sacrificing animals at 1, 4, 7, 21 or 35 days after dosing. Whole blood, plasma, erythrocytes, frontal cortex, hippocampus, striatum, hypothalamus and diaphragm tissue were collected and assayed for ChE activity. Collapsed across dosages, optimal correlations of blood ChE activity with brain or muscle activity occurred 7-21 days after dosing (when ChE inhibition was maximal and most stable). At all times after dosing, there was a high correlation among ChE activity in the hippocampus, striatum and frontal cortex. Generally, ChE activity in whole blood and erythrocytes correlated better with the activity in brain and ...Continue Reading

References

Mar 1, 1975·Analytical Biochemistry·C D Johnson, R L Russell
Dec 1, 1975·Journal of Neurochemistry·T L YakshH I Yamamura
Aug 1, 1973·Toxicology and Applied Pharmacology·L ReiterD Woolley
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE

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Citations

Jul 1, 2003·Indian Journal of Clinical Biochemistry : IJCB·Jyotsna A PatilSanjay P Govindwar
Mar 17, 2004·Neurotoxicology and Teratology·Fernando Sánchez-SantedDiana Cardona
Aug 18, 2001·Pharmacology, Biochemistry, and Behavior·V BailleG Lallement
Jan 1, 2009·Journal of Basic and Clinical Physiology and Pharmacology·Jyotsna A PatilSanjay P Govindwar
Sep 18, 2008·Arhiv za higijenu rada i toksikologiju·Fouad K MohammadMohammed M Al-Jobory
Jul 27, 2011·Environmental Toxicology and Pharmacology·Manal E A ElhalwagyGamila A M Kotb
Dec 7, 2007·Toxicology·Moslem MohammadiAlireza Asgari
Jan 1, 1996·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·G Dell'omoS K Fishwick
Feb 16, 2002·Regulatory Toxicology and Pharmacology : RTP·R C Cochran
Mar 12, 2013·International Journal of Biological Macromolecules·Bożena SosnowskaBożena Bukowska
May 10, 2016·Journal of Occupational and Environmental Medicine·Paul J LaurientiThomas A Arcury
Jan 18, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lucio G CostaClement E Furlong
Nov 6, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yacov Ashani, Shlomi Pistinner
Apr 3, 2018·Environmental Health : a Global Access Science Source·Jacqueline CottonSusan Brumby
Jan 1, 2008·Toxicology Mechanisms and Methods·Eugene DemchukChristopher T De Rosa
Mar 11, 2004·Journal of Enzyme Inhibition and Medicinal Chemistry·Marek BanasikRaymond D Harbison

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