PMID: 46266Mar 1, 1975

Studies on the cytophilic properties of human beta2 microglobulin

The Journal of Immunology : Official Journal of the American Association of Immunologists
C L AndersonH M Grey

Abstract

Human beta2 microglobulin is cytophilic for mouse, rat, and to a lesser extent guinea pig lymphocytes and polymorphonuclear leukocytes but not for human, rabbit, chicken, frog, and turtle cells, nor for any mature erythrocytes tested. Mouse splenic lymphocytes bind 5- 7-fold more beta2 microblobulin than thymocytes although hydrocortisone-resistant thymocytes resemble spleen cells in this regard. The beta2 microglobulin binding by B and T cells in mouse spleen is similar. The structure responsible for beta2 microglobulin binding to the surface of cells is distinct from the Fc receptor specific for aggregated IgG.

Related Concepts

Salientia
B-Lymphocytes
Beta(1)CA Globulin
Binding Sites, Antibody
Drug Resistance
Cavia porcellus
SD Antigens
Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer
Immune Sera
Iodine Radioisotopes

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