Studies on the Drug Loading and Release Profiles of Degradable Chitosan-Based Multilayer Films for Anticancer Treatment

Cancers
Hyeongdeok SunJinkee Hong

Abstract

This study demonstrates the possibility of developing a rapidly degradable chitosan-based multilayer film for controlled drug release. The chitosan (CHI)-based multilayer nanofilms were prepared with three different types of anions, hyaluronic acid (HA), alginic acid (ALG) and tannic acid (TA). Taking advantage of the Layer-by-Layer (LBL) assembly, each multilayer film has different morphology, porosity and thickness depending on their ionic density, molecular structure and the polymer functionality of the building blocks. We loaded drug models such as doxorubicin hydrochloride (DOX), fluorescein isothiocyanate (FITC) and ovalbumin (Ova) into multilayer films and analyzed the drug loading and release profiles in phosphate-buffered saline (PBS) buffer with the same osmolarity and temperature as the human body. Despite the rapid degradation of the multilayer film in a high pH and salt solution, the drug release profile can be controlled by increasing the functional group density, which results in interaction with the drug. In particular, the abundant carboxylate groups in the CHI/HA film increased the loading amount of DOX and decreased rapid drug release. The TA interaction with DOX via electrostatic interaction, hydrogen bondin...Continue Reading

References

Oct 3, 2001·The Journal of Antimicrobial Chemotherapy·H AkiyamaK Iwatsuki
Dec 26, 2001·Chemical Reviews·K E UhrichK M Shakesheff
May 24, 2003·Biomaterials·X H WangMark van der Werf
Feb 9, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Kris C WoodPaula T Hammond
Feb 11, 2005·Journal of the American Chemical Society·Benjamin ThierryMaryam Tabrizian
Mar 4, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Ludovic RichertCatherine Picart
May 10, 2005·Biomacromolecules·Susan E Burke, Christopher J Barrett
Jan 10, 2006·Biomacromolecules·Michael C BergMichael F Rubner
Apr 8, 2006·Biomaterials·Constant VodouhêPhilippe Lavalle
Jun 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kris C WoodPaula T Hammond
Feb 21, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Aurore SchneiderBenoit Frisch
Nov 17, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Weiyong YuanQin Zhou
Dec 1, 2007·Carbohydrate Research·David LealFrancesco Caruso
Oct 11, 2008·Biomacromolecules·Mireille WeijersRonald W Visschers
Jul 9, 2009·Chemical Communications : Chem Comm·Byeong-Su KimPaula T Hammond
Feb 13, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Xu WangJiacong Shen
Dec 24, 2013·International Journal of Biological Macromolecules·Yangchao Luo, Qin Wang
May 6, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kinam Park
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·S AnandhakumarA M Raichur
Jan 8, 2016·Journal of the American Chemical Society·Mark W TibbittRobert Langer
Apr 25, 2018·Carbohydrate Polymers·Petra MazancováFilip Rázga
Dec 26, 2018·Journal of Advanced Research·Sarwar HossenM Jalal Uddin
Aug 3, 2019·International Journal of Biological Macromolecules·Jing HuangHongbing Deng

❮ Previous
Next ❯

Methods Mentioned

BETA
AFM
atomic force microscopy
Infrared Spectroscopy
quartz crystal microbalance
irradiate

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.