PMID: 37852Jan 1, 1978

Studies on the effect of oxprenolol on experimentally induced anxiety (author's transl)

Arzneimittel-Forschung
K S LiuW Janke

Abstract

This experiment studied the question of whether the receptor blocking agent oxprenolol (20 mg) influences somatic and subjective responses to experimentally induced anxiety. 72 male students were Ss in a two-factorial design with type of drug (oxprenolol, placebo) and type of situation as the two factors. Anxiety was induced by the signaled application of shocks to one arm, under condition A with and under condition B without time control (clock available or not). Condition C was a control condition with neither shock nor time control. Heart rate, blood pressure and verbal reports of emotional experience were measured. An analysis of variance revealed the following: Oxprenolol showed physiological effects typical of a receptor blocking agent. The drug positively affected emotional experience not related to the experimentally induced anxiety but did not affect the emotional responses induced by the anxiety-provoking conditions. For explaining the results the possible meaning of the variable "internal vs external control of emotional responses" was considered.

Related Concepts

Diastolic Blood Pressure
Electroconvulsive Shock
Regret
Pulse Rate
Trasicor
Anti-Anxiety Effect

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.