PMID: 11309801Apr 20, 2001Paper

Studies on the effect of virtual crosslinking on the hydrolytic stability of novel aliphatic polyurethane ureas for blood contact applications

Journal of Biomedical Materials Research
V Thomas, M Jayabalan

Abstract

The effect of virtual crosslinking on the hydrolytic stability of completely aliphatic novel poly(urethane ureas), HFL9-PU1 (hard-segment content 57.5%) and HFL13-PU2 (hard-segment content 67.9%) based on 4,4'-methylene bis(cyclohexyl isocyanate) (H(12)MDI)-hydroxy-terminated polybutadiene-1,6-hexamethylene diamine, was studied. Fourier transform infrared-attenuated total reflectance and wide-angle X-ray diffraction studies revealed hydrogen-bonding interaction and microphase separation and formation of crystallites by short- and long-range ordering in hard-segment domains. Three-dimensional networks from hydrogen bonding in the present polymers lead to virtually crosslinking and insolubility. These polymers were noncytotoxic to L929 fibroblast cells. The hemolytic potential is below the accepted limit. The studies on in vitro biostability in Ringer's solution, phosphate buffered saline, and papain enzyme revealed no weight loss. The infrared spectral studies revealed changes in the surface, especially on HFL9-PU1 aged in Ringer's solution and phosphate buffered saline, and no changes when aged in papain. The marginal changes noticed in tensile properties were attributed to the changes in degree of hydrogen bonding and associat...Continue Reading

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Citations

Feb 29, 2008·Journal of Materials Science. Materials in Medicine·Vinoy Thomas, Jayabalan Muthu
May 13, 2009·Journal of Materials Science. Materials in Medicine·Pablo C CaraccioloGustavo A Abraham
Jul 3, 2013·Journal of Biomaterials Applications·J I Moo-EspinosaJ San Román del Barrio
Apr 24, 2008·Journal of Biomedical Materials Research. Part a·Vinoy Thomas, Muthu Jayabalan

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