PMID: 39574Jan 1, 1978

Studies on the effects of MJ-9184-1 in man

M van der StraetenR Pauwels


A new beta 2-adrenergic receptor stimulating drug, 2-hydroxy-5-[1-hydroxy-2-(2-methyl-1-phenyl-2-propyl-amino)-ethyl]-methanesulfonanilide hydrochloride (MJ-9184-1), was found to be a potent bronchodilator in man. In double-blind cross-over study including placebo, 0.25 mg and 0.50 mg MJ-9184-1 and involving ten patients with stable chronic obstructive lung disease with reversible airways obstruction, MJ-9184-1 caused a fast-appearing and long-lasting bronchodilator effect. The oral intake of 0.50 mg MJ-9184-1, compared to 0.25 mg, caused a more rapid effect and a more pronounced bronchodilation; 0.50 mg MJ-9184-1 also caused some elevation of the pulse rate. The effect was not seen after 0.25 mg MJ-9184-1.

Related Concepts

Physiologic Pulse
Airway Resistance
Broncholytic Effect
Adrenergic beta-Agonists
Bronchodilator Effect
Bronchodilator Agents
Adrenergic Receptor

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.