PMID: 6405797May 25, 1983Paper

Studies on the fate of aldolase molecules in the aging rat lens

Biochimica Et Biophysica Acta
A Dovrat, D Gershon

Abstract

It was found that aldolase activity declined considerably in the lens of adult animals with increasing age. Immunoassay showed that defective aldolase C molecules were accumulated. In addition, antibody prepared against denatured enzyme preferentially removes inactive molecules from lens homogenates without affecting active molecules. It is concluded that defective aldolase molecules encountered in aging lenses are at least partially denatured and are inactive.

References

Feb 1, 1979·Mechanisms of Ageing and Development·D Gershon
Jan 26, 1972·Biochimica Et Biophysica Acta·O Vesterberg
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·H Gershon, D Gershon
Nov 1, 1969·Biochemistry·E E PenhoetW J Rutter
Jan 15, 1982·The Biochemical Journal·L LavieD Gershon

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Citations

Jan 1, 1987·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J ScharfD Gershon
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A Z ReznickD Gershon
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K C Yuh, A Gafni
Nov 9, 2006·Free Radical Research·Earl R Stadtman
Feb 14, 2002·Archives of Biochemistry and Biophysics·Kenneth Hensley, Robert A Floyd
Jun 1, 1985·Journal of Bacteriology·H M Steinman
Dec 1, 1985·Experimental Eye Research·I A Skipski, W N Scott

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