PMID: 7088251Mar 1, 1982Paper

Studies on the flavor aversions induced by trialkyltin compounds

Neurobehavioral Toxicology and Teratology
R C MacPhail


These experiments were undertaken to determine the suitability of a flavor-aversion-conditioning paradigm for detecting the effects of trimethyltin and triethyltin. Both organotins produced flavor aversions whose magnitude depended jointly on the dosage administered and the number of flavor-organotin pairings. Estimated ED 50s (for triethyltin, 1.8 mg/kg; for trimethyltin, 3.1 mg/kg) were smaller than the dosages reported to affect other classes of behavior, but nevertheless represented a substantial percentage (25-45%) of the respective published LG-50 values. Flavor-aversion conditioning may represent a valuable tool for studying the effects of organic and inorganic heavy metals.

Related Concepts

Conditioning (Psychology)
Lethal Dose 50
Taste Perception
Trialkyltin Compounds
Triethyltin Compounds
Trimethyltin Compounds

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