PMID: 13563757Aug 1, 1958Paper

Studies on the formation of collagen. III. Time-dependent solubility changes of collagen in vitro

The Journal of Experimental Medicine
J Gross

Abstract

Precipitation (or gelation) of collagen from cold neutral salt solution induced by warming was shown to be reversible on subsequent cooling. The degree of reversibility of heat precipitation rapidly diminished with time of incubation at 37 degrees C. For calf skin collagen (acetic acid-extracted) and guinea pig skin collagen (crude NaCl extract) in neutral salt solutions (Gamma/2 = 0.45) roughly 90 per cent of newly formed gel redissolved on cooling at 2 degrees C.; less than 20 per cent redissolved on cooling gels previously maintained at 37 degrees C. for 24 hours. At physiologic ionic strength the same preparations exhibited much more rapid development of irreversible precipitation, but the same time dependence was clearly evident. Highly purified collagen from crude saline extracts of guinea pig skin exhibited the same phenomenon although the quantitative aspects were somewhat different.

References

Jul 25, 1956·The Journal of Biophysical and Biochemical Cytology·J GROSS
Jan 15, 1955·Proceedings of the National Academy of Sciences of the United States of America·J GrossF O Schmitt

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Citations

Jul 1, 1991·Journal of Biomedical Materials Research·J N GadeJ P Bentley
Jan 1, 1974·Journal of Supramolecular Structure·J H Fessler
May 1, 1977·The Laryngoscope·M Abramson, C C Huang
Jun 1, 1968·American Journal of Orthodontics·J G Edwards
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Oct 1, 1980·Thrombosis Research·E F Bernstein, U M Marzec
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Apr 25, 1966·Biochimica Et Biophysica Acta·J H Fessler, A J Bailey
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Jan 1, 1980·Experimental Gerontology·S C Gantayat, B K Patnaik
Jan 1, 1982·Experimental Gerontology·J S RaoS M Bose
Oct 1, 1984·Collagen and Related Research·H G WelgusG P Stricklin
Feb 1, 1960·Proceedings of the National Academy of Sciences of the United States of America·A J HodgeF O Schmitt
Nov 1, 1961·Biological Reviews of the Cambridge Philosophical Society·R D HARKNESS
Jan 1, 1968·Acta Physiologica Scandinavica. Supplementum·E Heikkinen
Dec 1, 1963·The Journal of Pharmacy and Pharmacology·G C WOOD
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May 1, 1970·Archives of Biochemistry and Biophysics·E Schiffmann, G R Martin
Nov 1, 1959·Journal of Chronic Diseases·A DORFMAN
Jul 16, 1963·Biochimica Et Biophysica Acta·J GROSS
Nov 1, 1959·Journal of Dental Research·J A YAEGER
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Jan 1, 1973·Community Mental Health Journal·S Eisenthal
Jan 1, 1973·Community Mental Health Journal·S Eisenthal, W I Malamud
Aug 1, 1961·Circulation·I R KONIGSBERG
Jan 1, 1964·Acta Pathologica Et Microbiologica Scandinavica·T MAJANIEMI, E KULONEN
Nov 29, 1964·Biochimica Et Biophysica Acta·J K CANDLISH, G R TRISTRAM
Jun 22, 1973·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·P BartlettK Ashworth
Aug 31, 1972·Biochimica Et Biophysica Acta·E D Harris, M E Farrell
Apr 11, 1974·Biochimica Et Biophysica Acta·C M Lapiere, B Nusgens
May 13, 1961·Biochimica Et Biophysica Acta·G R MARTIND B SCOTT
Oct 23, 1967·Biochimica Et Biophysica Acta·J Bello, H R Bello

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