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Studies on the galactose-binding site of ricin and the hybrid toxin Man6P-ricin

Cell

Feb 1, 1981

R J YouleD M Neville

PMID: 7471212

Abstract

N-acetylimidazole (NAI) was used to O-acetylate the plant seed toxin ricin. O-acetylation of one to two tyrosine residues per molecule of ricin inhibited ricin binding to Sepharose 4B and decreased toxicity by 90% in a protein synthesis inhibition assay in HeLa cells. Lactose, known to ...read more

Mentioned in this Paper

Galactose Measurement
Specimen Type - Fibroblasts
RRNA N-glycosidase Activity
Toxin
N-acetylimidazole
Hydroxylamines
Galactose
Neuraminidase
Ligand Binding Domain
Protein Acetylation
Paper Details
References
  • References16
  • Citations40
12
  • References16
  • Citations40
1234

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The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society

Cytotoxicity of KDEL-terminated ricin toxins correlates with distribution of the KDEL receptor in the Golgi

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E P TaggeA E Frankel
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Studies on the galactose-binding site of ricin and the hybrid toxin Man6P-ricin

Cell

Feb 1, 1981

R J YouleD M Neville

PMID: 7471212

DOI:

Abstract

N-acetylimidazole (NAI) was used to O-acetylate the plant seed toxin ricin. O-acetylation of one to two tyrosine residues per molecule of ricin inhibited ricin binding to Sepharose 4B and decreased toxicity by 90% in a protein synthesis inhibition assay in HeLa cells. Lactose, known to ...read more

Mentioned in this Paper

Galactose Measurement
Specimen Type - Fibroblasts
RRNA N-glycosidase Activity
Toxin
N-acetylimidazole
Hydroxylamines
Galactose
Neuraminidase
Ligand Binding Domain
Protein Acetylation

Similar Papers Found In These Feeds

General Biology Journal eTOCs

Discover the latest general biology research in this collection of the top biology journals.

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Synergy of ricin A chain-containing immunotoxins and ricin B chain-containing immunotoxins in in vitro killing of neoplastic human B cells

Proceedings of the National Academy of Sciences of the United States of AmericaOctober 1, 1983
E S VitettaJ W Uhr
The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society

Cytotoxicity of KDEL-terminated ricin toxins correlates with distribution of the KDEL receptor in the Golgi

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry SocietyFebruary 1, 1996
E P TaggeA E Frankel
Paper Details
References
  • References16
  • Citations40
12
  • References16
  • Citations40
1234
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