PMID: 4907958Feb 1, 1970Paper

Studies on the heterogeneity of human gastric zymogens

The Biochemical Journal
M D TurnerH L Segal

Abstract

THE PEPTIC ZYMOGENS OF HUMAN GASTRIC MUCOSA HAVE BEEN STUDIED IN THE PAST BY THREE DIFFERENT TECHNIQUES: phosphate-gradient chromatography on a column of DEAE-cellulose, chloride-gradient chromatography on DEAE-cellulose and agar-gel electrophoresis. These techniques have given different results, each suggesting the presence of a different number of pepsin zymogens in human gastric mucosa. In the present experiments gastric mucosal homogenates were subjected to analysis by all three techniques. The two major zymogen peaks obtained from phosphate-gradient chromatography were found to be composed of the three fractions found on chloride-gradient chromatography; these fractions in turn were shown to be heterogeneous on agar-gel electrophoresis. The latter technique demonstrated the presence of seven separable enzymically active components in human gastric mucosal homogenates. The relationships of the components separated by the three techniques are discussed.

Citations

Jan 1, 1978·Gastroenterologia Japonica·K Kojima, M Moriga
Oct 1, 1973·The American Journal of Digestive Diseases·J C ManglaM D Turner
Jan 1, 1977·Gastroenterologia Japonica·K MurakamiK Kawai
Jul 15, 1979·Klinische Wochenschrift·T Becker, W Rapp
Mar 1, 1974·The American Journal of Digestive Diseases·J C Mangla, Y Kim
Oct 1, 1970·Gut·M D TurnerH L Segal
May 1, 1982·The Journal of Urology·P H WardL Chiang
Apr 14, 1976·Biochimica Et Biophysica Acta·M ZöllerW Rapp
Apr 28, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·K MatsusakoR Tanaka
Jan 1, 1978·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·P H WardL Chiang
Jan 1, 1984·Comparative Biochemistry and Physiology. A, Comparative Physiology·N M Abuharfeel, G M Abuereish
Jun 1, 1975·Biochemical Medicine·J C ManglaM D Turner
Dec 1, 1972·Analytical Biochemistry·K Murakami, M D Turner

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