Studies on the hydrolysis of 1-alk-1'-enyl-sn-glycero-3-phosphoethanolamine by microsomes from myelinating rat brain

Hoppe-Seyler's Zeitschrift für physiologische Chemie
J GunawanH Debuch

Abstract

Microsomal fractions of 14-day-old rat brain were incubated at pH 7.1 with 1-[1'-14C]-alk-1'-enyl-sn-glycero-3-phosphoethanolamine (lysoplasmalogen). 1-[1'-14C]alkenylglycerol was produced by hydrolyzing enzyme activities, which were stimulated by Mg2 and inhibited by SH-group reagents. Hydrolysis of 1-[1'-14C]alkyl-sn-glycero-3-phosphoethanolamine is very similar in this respect, but the Km value is higher in the former case. The 1-alkyl compound acts as a non-competitive inhibitor of the hydrolyzing enzyme activity described, whereas the hydrolysis of the 1-alkyl derivative is not inhibited by the 1-alkenyl compound.

Citations

Dec 1, 1987·Molecular and Biochemical Parasitology·V Achterberg, G Gercken
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·T VartanianS Szuchet
Dec 3, 2014·Biochimica Et Biophysica Acta·Marianne S JurkowitzCharles E Bell
Feb 1, 1983·Analytical Biochemistry·N M Freeman, E M Carey
Feb 1, 1985·Journal of Neurochemistry·J Gunawan, H Debuch
Sep 1, 1982·Journal of Neurochemistry·J Gunawan, H Debuch

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