Studies on the in vitro biological N-oxidation of trimethoprim

European Journal of Drug Metabolism and Pharmacokinetics
P J Watkins, J W Gorrod

Abstract

In vivo studies on the metabolism of trimethoprim have shown that N-oxidation to isomeric N-oxides occurs, with considerable inter-species variation in the proportion of each N-oxide excreted. No in vitro studies on the metabolism of trimethoprim have been reported to date. We now report a sensitive and specific HPLC method for the simultaneous determination of the isomeric N-oxides of trimethoprim. In vitro metabolic studies with hepatic microsomes from several animal species have been conducted. Optimum incubation conditions have been established and the use of potential metabolic inducers, activators and inhibitors has demonstrated that the N-oxidation of trimethoprim to its isomeric N-oxides is mediated via a cytochrome P450 dependent pathway.

References

Aug 1, 1975·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J W GorrodA H Beckett
Apr 1, 1979·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J W Gorrod, L A Damani
Oct 1, 1987·European Journal of Drug Metabolism and Pharmacokinetics·K el-Ghomari, J W Gorrod
Apr 1, 1973·Journal of Pharmaceutical Sciences·C W Sigel, D A Brent
Nov 1, 1973·The Journal of Infectious Diseases·C W SigelC A Nichol
May 1, 1972·Archives of Biochemistry and Biophysics·D M Ziegler, C H Mitchell
May 1, 1970·The Journal of Organic Chemistry·J Cymerman Craig, K K Purushothaman
Sep 1, 1983·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J W Gorrod, L H Patterson
Aug 1, 1956·The Biochemical Journal·J AXELROD

❮ Previous
Next ❯

Citations

Oct 1, 1987·European Journal of Drug Metabolism and Pharmacokinetics·K el-Ghomari, J W Gorrod
Mar 26, 1998·European Journal of Drug Metabolism and Pharmacokinetics·J W Gorrod, T G Altuntas
Oct 1, 1993·Environmental Health Perspectives·J W GorrodS Neville
Jun 1, 1989·The Journal of Pharmacy and Pharmacology·S P LamJ W Gorrod
Jan 1, 1995·Drug Metabolism and Drug Interactions·T G Altuntas, J W Gorrod
Jan 1, 1991·Pharmacology & Therapeutics·R E White

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Related Papers

European Journal of Drug Metabolism and Pharmacokinetics
K el-Ghomari, J W Gorrod
European Journal of Drug Metabolism and Pharmacokinetics
S P LamJ W Gorrod
© 2021 Meta ULC. All rights reserved