Studies on the inhibition of adrenaline-induced aggregation of blood platelets

Pharmacology
E GlusaW Barthel

Abstract

alpha-Adrenoceptors of platelets seem to differ from those of other cell types. The inhibitory effect of alpha-adrenoceptor-blocking agents on adrenaline-induced aggregation of human platelets does not parallel that on adrenaline-induced contraction of rabbit aortic strips. The most potent inhibitors of adrenaline-induced platelet aggregation are the dihydrogenated ergot alkaloids of the peptide type. Among the other ergoline derivatives testes, only lisuride has a stronger inhibitory effect than those of natural ergot alkaloids.

Citations

Mar 1, 1985·Biulleten' eksperimental'noĭ biologii i meditsiny·S P Golyshenkov, V P Skipetrov
Jun 1, 1988·Clinical and Experimental Pharmacology & Physiology·G AnfossiG Emanuelli
Jul 15, 1989·Thrombosis Research·E GlusaS Heptinstall
Feb 1, 1984·Biochemical Pharmacology·E Glusa, F Markwardt
Feb 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·W Kobinger
Dec 31, 1980·Biochemical and Biophysical Research Communications·H J MotulskyP A Insel

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