Aug 1, 1989

Studies on the interaction between mitochondria and the cytoskeleton

Journal of Bioenergetics and Biomembranes
M LindénJ F Leterrier


Mitochondrial movements and morphology are regulated through interactions with the cytoskeletal system, in particular the microtubules. An interaction between the microtubule-associated proteins (MAPs) and the outer surface of rat brain mitochondria has been demonstrated in vitro and in situ. One of the MAPs, MAP2, binds to specific high-affinity sites on the outer membrane. Upon binding, MAP2 is released from microtubules, and it induces a physical alteration in the outer membrane which is characterized by a tighter association of porin with the membrane. It is concluded that MAP2 either binds to porin or to a domain of the outer membrane which alters the membrane environment of porin. The possibility is raised that this domain participates in mitochondrial mobility in situ.

Mentioned in this Paper

Microtubule-Associated Proteins
Microtubule-Associated Protein 3
Outer Membrane
Science of Morphology
MAP2 gene
Porin Activity
Ion Channel

About this Paper

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