Studies on the interactions between parabens and lipid membrane components in monolayers at the air/aqueous solution interface

Biochimica Et Biophysica Acta
Michał FlasińskiPaweł Wydro

Abstract

The interactions between parabens (PBs) and lipid components of mammalian and bacterial cell membranes were investigated in model systems of Langmuir monolayers. Me-, Et-, Pr- and Bu-paraben studied in this paper are frequently applied as cosmetics and food preservatives, since they possess broad antimicrobial activity. The mode of PB action is connected with their incorporation into the membrane of bacterial organisms, however; it is not known what is the role of the respective lipid species in this mechanism. This problem is crucial to understand the differences in paraben activity toward individual microorganisms and to shed the light onto the problem of PB cytotoxicity reported in studies on mammalian cells. In this paper, the mentioned aspects were investigated with application of the Langmuir monolayer technique complemented with BAM and GIXD. Our experiments revealed that the influence of PBs depends on their chemical structure, solution concentration and on the class of lipid. The strongest modification of the monolayer characteristics, leading to its collapse at low surface pressure, occurred in the presence of BuPB, having the largest chain. PBs interact preferentially with the monolayers possessing low degree of cond...Continue Reading

References

Jan 6, 1999·Toxicology and Applied Pharmacology·E J RoutledgeJ P Sumpter
Jan 9, 2003·Journal of Applied Toxicology : JAT·P D DarbreM J Sauer
Sep 17, 2003·Journal of Applied Toxicology : JAT·Philip W Harvey
Dec 31, 2003·Journal of Colloid and Interface Science·Amélia M Gonçalves da SilvaJuan M Rodríguez Patino
Mar 15, 2005·Biophysical Journal·T Zaraiskaya, K R Jeffrey
Apr 13, 2005·The Journal of Antimicrobial Chemotherapy·Jérôme BredinJean-Marie Pagès
Apr 19, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M G SoniG A Burdock
Apr 19, 2005·Obesity Research·Terry L Davidson, Susan E Swithers
Jun 30, 2007·Biochimica Et Biophysica Acta·Raquel F EpandRichard M Epand
Nov 21, 2007·Journal of Clinical Pharmacy and Therapeutics·C Charnock, T Finsrud
Oct 2, 2008·Journal of the American Chemical Society·Richard M EpandRaquel F Epand
Apr 13, 2010·Reproductive Toxicology·Julie BobergUlla Hass
Dec 17, 2010·Colloids and Surfaces. B, Biointerfaces·Thais de Paula RigolettoLucimara Gaziola de la Torre
Sep 10, 2011·Journal of Colloid and Interface Science·Katarzyna Hąc-WydroJarosław Majewski
Sep 8, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Pan HuLing Zhao
Mar 25, 2014·Environment International·Dorota BłędzkaWojciech Wąsowicz
Dec 3, 2014·Water Research·Camille HamanJean-François Munoz

❮ Previous
Next ❯

Citations

Jul 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dániel NemesIldikó Bácskay
Aug 19, 2017·Biosensors·Carmen M González-HenríquezClaudio A Terraza
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Hongchao ZhangStratton T Wimsatt
Feb 13, 2018·The Journal of Physical Chemistry. B·Michał FlasińskiPaweł Wydro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.