PMID: 7128924Oct 1, 1982

Studies on the kinetics of dopamine-regulated prolactin secretion

Molecular and Cellular Endocrinology
I M Kramer, C R Hopkins

Abstract

The regulation of prolactin (PRL) release by dopamine has been studied using short-term dissociated rat pituitary cell cultures. Concentrations of dopamine between 10(-12) and 10(-10) M stimulate PRL release, whereas concentrations between 10(-9) and 10(-7) M inhibit. By studying the kinetics of PRL release it was found that (1) the rate of PRL release increases only after a post-stimulus delay of 20 min, and (2) the response is phasic, stimulatory intervals being separated by intervals in which the rate of PRL release falls below the level of basal release. Inhibition of PRL release by dopamine occurs within 10 min after adding dopamine and is maintained tonically for a least 2 h. Cells treated with non-specific secretogogue (57 mM K+) during the inhibitory phases of dopamine-regulated release, are stimulated to secrete significant amounts of hormone.

References

Aug 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J C HutsonP J Gardner
Jan 1, 1978·Neuroendocrinology·M A Calabro, R M MacLeod
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·C MukherjeeR J Lefkowitz
May 22, 1980·Nature·C DenefR Dewals

Citations

Apr 1, 1986·Molecular and Cellular Endocrinology·A DuttH S Juneja
Mar 1, 1997·The Journal of Pharmacy and Pharmacology·S GiacomelliG De Feo
Dec 17, 2009·International Journal of Endocrinology·M K Gill-Sharma
Apr 1, 1994·Trends in Endocrinology and Metabolism : TEM·L Stephen Frawley
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese
Oct 4, 2000·Physiological Reviews·Marc E FreemanG Nagy
Oct 8, 1997·The American Journal of Physiology·S H ShinG M Ross
Nov 1, 1994·The American Journal of Physiology·K A GregersonR Chuknyiska

Related Concepts

Intropin
Dose-Response Relationship, Drug
Pituitary Stalk
Potassium
Prolactin
August Rats

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