Jan 1, 1975

Studies on the latency of rat liver fumarate hydratase

Enzyme
J Szkudlarek, W Turski

Abstract

A hypotonic medium and nonionic detergents Triton X-100 and digitonin have no influence on the activity of fumarase in the homogenate or in the mitochondrial fraction either. Ionic detergents of deoxycholate, cholate and sodium dodecyl sulphate exert an inhibiting influence. The activity of enzyme was determined in an L-malate-fumarate system. 1 h of incubation and the original Racker's method gave similar results. The lack of 'latency', found for the mitochondrial fumarase, was discussed basing on the data concerned with the penetration of metabolites through the inner mitochondrial membrane.

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Mentioned in this Paper

Paraparesis
Exertion
Digitonin
Mitochondria, Liver
Fumarate
Cholate
Mitochondria
Deoxycholate
Deoxycholic Acid, Sodium Salt, 12beta-Isomer
Cholic Acids

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