PMID: 8953504Oct 1, 1996Paper

Studies on the magnitude and the mechanism of cough potentiation by angiotensin-converting enzyme inhibitors in guinea-pigs: involvement of bradykinin in the potentiation

The Journal of Pharmacy and Pharmacology
K TakahamaT Miyata

Abstract

One adverse effect of the angiotensin-converting enzyme (ACE) inhibitors used for treatment of hypertension and congestive heart failure is the production of dry coughs. Imidapril is a new type of ACE inhibitor with a very low incidence of coughs. The magnitude and the mechanism of cough potentiation of imidapril and other ACE inhibitors has been studied in guinea-pigs. In normal guinea-pigs single and repeated dosing of imidapril at 0.1 to 100 mg kg-1 had no effect on capasaicin- or citric acid-induced coughs. Single and repeated dosing of enalapril and captopril at 10 to 30 mg kg-1, respectively, significantly increased the number of capsaicin-induced coughs. Repeated dosing of 1 mg kg-1 enalapril also significantly augmented the capsaicin cough. In bronchitic guinea-pigs imidapril also had no effect on the coughs induced by the two stimulants. Enalapril and captopril significantly increased the number of coughs induced not only by capsaicin but also by citric acid. Lower doses of enalapril were enough to augment the capsaicin-induced coughs, whereas medium to large doses failed to augment the cough irrespective of the protocol of administration. Bradykinin-induced discharges of the vegal afferents from the lower airway were ...Continue Reading

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Citations

Sep 18, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Cecilia CialdaiCarlo Alberto Maggi
Oct 18, 2003·The American Journal of Medicine·Robert DiBianco
Aug 19, 2003·European Journal of Pharmacology·Rikiya HirataShigekatsu Kohno
Jan 16, 1998·European Journal of Pharmacology·S MatsubaraK Ikezawa
Sep 2, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Takeshi Miyata
Jun 17, 2008·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Kazuo TakahamaJian Rong Zhou
May 21, 2015·Clinical and Experimental Hypertension : CHE·Atsuhisa Sato, Seiichi Fukuda
Feb 24, 2015·Current Opinion in Pharmacology·Thomas E Taylor-Clark
Sep 11, 2016·Pulmonary Pharmacology & Therapeutics·Janiana Raíza Jentsch Matias de OliveiraEunice André
Dec 24, 2003·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Takeshi Miyata
Oct 7, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Donatella MutoloTito Pantaleo
Feb 9, 2007·Journal of Pharmacological Sciences·Takeshi Miyata

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