PMID: 5853075Nov 1, 1965Paper

Studies on the mechanism of action of Riley virus. I. Action of substances affecting the reticuloendothelial system on plasma enzyme levels in mice

The Journal of Experimental Medicine
B W MahyM H Salaman

Abstract

Plasma LDH levels were determined in normal and Riley virus-infected mice following treatment with various drugs known to alter the activity of the RES. The rise in plasma LDH level after Riley virus infection was considerably enhanced by previous treatment with thorotrast (to produce blockade of the RES), and decreased by previous treatment with stilboestrol (to stimulate the RES). A dose of 2000 r whole-body x-irradiation, lethal within 3 to 4 days, did not alter the phagocytic activity of the RES, and was without effect on plasma LDH activity in normal mice, or on the rise in plasma LDH level following infection with Riley virus. Blockade of the RES with cholesterol oleate, thorotrast, or zymosan, resulted in a 2- to 3-fold rise in plasma LDH level within a few hours. The level returned to normal by 1 to 3 days. Stimulation of the RES with stilboestrol resulted in a decrease in plasma LDH level by 1 to 2 days in both normal and infected mice, with a return to normal by about a week. Blockade of the RES in uninfected mice with thorotrast or cholesterol oleate, besides increasing the plasma LDH level caused a rise in plasma phosphoglucose isomerase level, but no significant alterations in plasma aldolase or alanine transaminas...Continue Reading

References

Oct 1, 1955·Proceedings of the Society for Experimental Biology and Medicine·F WROBLEWSKI, J S LADUE
Apr 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·F WROBLEWSKI, J S LADUE
May 1, 1961·Clinica Chimica Acta; International Journal of Clinical Chemistry·E J KING, D M CAMPBELL
Dec 1, 1959·The Journal of Clinical Investigation·P E STRANDJORDL P WHITE
Aug 1, 1963·Journal of Pharmaceutical Sciences·H SALEMD L BILBEY
Apr 1, 1964·The Journal of Pathology and Bacteriology·A E STUART, A E DAVIDSON
May 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·F J DICARLOG E PHILLIPS
Aug 1, 1964·Virology·B W MahyM H Salaman
Aug 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·J G CAPPUCCINOG C PERRI
Nov 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·J M BAILEYM STEARMAN

Citations

Jan 1, 1988·Veterinary Research Communications·G Lussier
Jun 1, 1966·The Journal of Experimental Medicine·H G Du Buy, M L Johnson
Feb 1, 1975·Behavioral Biology·L R Taylor, D J Costanzo
Apr 1, 1975·Journal of Comparative Pathology·E StauberR Piper

Related Concepts

SGPT - Glutamate pyruvate transaminase
Epicholesterol
Distilbène
Aldolase C
Isomerase
Lactate Dehydrogenase
Oncogenic Viruses
Phagocytosis
Effects of Radiation
Reticuloendothelial System

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