Studies on the mechanism of action of various vasodilators

British Journal of Pharmacology
G GagnonF Rioux

Abstract

1 The vascular relaxant effects of histamine, adenosine, isoprenaline nitroglycerine, papaverine and 3-isobutyl-l-methylxanthine (IBMX) were assessed individually, in strips of rabbit renal artery moderately contracted with noradrenaline (NA) in the absence or presence of phosphodiesterase inhibitors (papaverine and IBMX) or verapamil, a Ca(2+) antagonist.2 The vasodilator effect of histamine was potentiated by papaverine (6.1 x 10(-7) M) and IBMX (4.4 x 10(-5) M) but inhibited dose-dependently by verapamil (5.1 and 51.0 x 10(-7) M).3 Adenosine-induced vascular relaxations were greatly increased in the presence of papaverine (6.1 x 10(-7) M) but significantly reduced in the presence of IBMX (4.4 x 10(-5) M) or verapamil (5.1 and 51.0 x 10(-7) M).4 The vasodilatation produced by isoprenaline was increased in the presence of IBMX (4.4 x 10(-5) M) or papaverine (6.1 x 10(-7) M), but inhibited by verapamil (5.1 and 51.0 x 10(-7) M).5 The vascular relaxant effects of nitroglycerine and papaverine were inhibited in the presence of IBMX (4.4 x 10(-5) M) or verapamil (5.1 and 51.0 x 10(-7) M). Papaverine (6.1 x 10(-7) M) also antagonized nitroglycerine-induced vascular relaxation.6 The vasodilator effect of IBMX was greatly reduced in ...Continue Reading

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Citations

Sep 1, 1984·Basic Research in Cardiology·P DuttaS J Mustafa
Dec 23, 1983·European Journal of Pharmacology·A SubissiM Bachi
Jan 1, 1983·Pharmacology & Therapeutics·S Lipe, R F Moulds
Apr 1, 1989·The Journal of Pharmacy and Pharmacology·A Ubeda, A Villar
Jun 22, 1984·The American Journal of Medicine·M PackerW H Lee
Jun 25, 1986·Brain Research·L RecioM Lopez-Rico
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amato J Giaccia
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
Sep 12, 2018·Proceedings of the National Academy of Sciences of the United States of America·Martin BenejNicholas C Denko
Sep 1, 1984·Acta Pharmacologica Et Toxicologica·O Strubelt
Oct 5, 2017·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Kenneth L Byron, Lyubov I Brueggemann
Apr 12, 1982·Life Sciences·H H Shlevin

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