Studies on the mechanism of action of acetylcholine antagonists on rat parasympathetic ganglion cells

The Journal of Physiology
P AscherH P Rang

Abstract

The mode of action of ACh antagonists on the parasympathetic neurones of the submandibular ganglion of the rat was studied by means of a two-micro-electrode voltage-clamp technique. The currents produced by various agonists (carbachol, ACh, suberylcholine) were studied in steady state and after voltage steps, before and after perfusion of various antagonists. 2. For three antagonists (tubocurarine, hexamethonium, decamethonium) the blocking action increases with hyperpolarization. For three other antagonists (surugatoxin, trimetaphan, mecamylamine) the effects observed at low concentrations appear to be independent of membrane potential, although in some cases voltage dependence of the block was observed for mecamylamine. 3. The blocks the 'open' channel-reception complex. The block produced by tubocurarine, hexamethonium and decamethonium increases with the agonist concentration, an observation which supports a 'sequential' scheme in which the antagonist blocks the 'open' channel-receptor complex. The block produced by trimetaphan and mecamylamine decreases slightly with increased agonist concentration, which in turn suggests that these two compounds are competitive antagonists, preventing binding of the agonists to the closed...Continue Reading

References

Mar 29, 2013·Autonomic Neuroscience : Basic & Clinical·Raj K Goyal, Arun Chaudhury
Jan 1, 1988·Neir̆ofiziologiia = Neurophysiology·A A SeliankoVladimir I Skok
Oct 12, 2014·Molecular and Cellular Neurosciences·Alexey V RossokhinVladimir G Skrebitsky
Oct 26, 2010·Research in Veterinary Science·Sasa M TrailovicVladislav M Varagić
Jul 28, 1999·European Journal of Pharmacology·K Nakazawa, Y Ohno
Jun 1, 1995·Neuropharmacology·J L Galzi, J P Changeux
Aug 21, 1980·The Journal of Membrane Biology·D Marchais, A Marty
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·O W WitteJ Walden
Jan 1, 1981·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·J E Chad, G A Kerkut
Oct 17, 2007·European Biophysics Journal : EBJ·Konstantin OstroumovAndrey Skorinkin
Jan 7, 1999·The Journal of Pharmacy and Pharmacology·Z G GaoC G Liu
Apr 1, 1991·Pflügers Archiv : European journal of physiology·K NakazawaA Takanaka
Aug 1, 1991·Pflügers Archiv : European journal of physiology·M Inoue, H Kuriyama
Apr 1, 1995·Progress in Neurobiology·T Akasu, T Nishimura
Aug 1, 1994·Journal of the Autonomic Nervous System·D E KurennyVladimir I Skok
Nov 1, 1982·Journal of the Autonomic Nervous System·N Y Lukomskaya, V E Gmiro
Jul 1, 1982·Journal of the Autonomic Nervous System·A A SelyankoVladimir I Skok
Jan 1, 1988·Experimental Brain Research·D ParkinsonN W Daw
Apr 20, 1999·Pharmacology, Biochemistry, and Behavior·S S WatkinsA Markou
Dec 1, 1989·Pharmacology, Biochemistry, and Behavior·Y GomitaY Araki
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·A C CollinsM J Marks
Sep 21, 2002·Autonomic Neuroscience : Basic & Clinical·Andrei Yu Bobryshev, Vladimir I Skok
Sep 1, 1984·Cellular and Molecular Neurobiology·N T Slater, D O Carpenter
Jan 1, 1981·Pharmacology & Therapeutics·B J Morley
Oct 26, 1992·Neuroscience Letters·D BertrandM Ballivet
Jan 1, 1990·Neuroscience Letters·J J Galligan, R A North
Aug 27, 2014·Scientific Reports·Shogo FurutaniKazuhiko Matsuda

Related Concepts

Study
Microelectrodes
Physiologic Pulse
Mecamylamine
Block Dosage Form
Cholinergic Agonists
Carboptic
Membrane
Toxin
Resting Potentials

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.