PMID: 13673141Aug 1, 1959

Studies on the mechanism of hypersensitivity phenomena. III. The participation of complement in the formation of anaphylatoxin

The Journal of Experimental Medicine


The interaction of fresh rat and guinea pig serum with washed preformed immune aggregates has been studied with respect to the loss in hemolytic potency of the serum, diminution of the C'(3); activity, and appearance of anaphylatoxin. It has been found that the formation of anaphylatoxin, as judged by its effect on capillary permeability and smooth muscle contraction, is coincident with or subsequent to the fixation of all the known C' components. Less anaphylatoxin is formed by aggregates formed with excess antigen than those in equivalence ratio combination. C' fixation, as well as anaphylatoxin production, may be inhibited by chelation of the divalent cations, presumably by interfering with the fixation of C'(1), C'(4), and C'(2). Phlorizin suppresses the utilization of C'(3) in immune hemolysis, C' fixation by antigen-antibody aggregates, and the production of anaphylatoxin. The biological activities associated with the fixation of C' are not manifest unless C'(3) participates in this process at 37 degrees C. It is concluded that the formation of anaphylatoxin may be regarded as a product of C' fixation.


Mar 1, 1956·The Journal of Pediatrics·K L BURDON
Jun 1, 1956·British Journal of Pharmacology and Chemotherapy·C G HAINING
Sep 1, 1956·British Journal of Pharmacology and Chemotherapy·E M ROCHA SILVA, A M ROTHSCHILD
Jan 1, 1957·International Archives of Allergy and Applied Immunology·F HAHN
Mar 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·K ISHIZAKA, D H CAMPBELL
Oct 1, 1958·The Journal of Experimental Medicine·R A NELSON
Dec 1, 1958·Archives of Biochemistry and Biophysics·E A KABAT, A E BEZER
Feb 1, 1951·Proceedings of the Society for Experimental Biology and Medicine·A B VOORHEESE J PULASKI
Apr 1, 1951·The Review of Scientific Instruments·S A TALBOTL W REYNOLDS
Apr 12, 1952·British Medical Journal·M ROCHA E SILVA
Jul 19, 1952·Nature·T EDLUNDL VALI


Jan 1, 1969·Naunyn-Schmiedebergs Archiv Für Pharmakologie·W Vogt, J Lyncker
Feb 26, 1998·Immunopharmacology·J F Regal
Jan 1, 1989·Pulmonary Pharmacology·J F Regal
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C Gerard, T E Hugli
Nov 1, 1961·The Journal of Experimental Medicine·M B RHYNE, F G GERMUTH
May 1, 1967·The Journal of Experimental Medicine·H A BladenS E Mergenhagen
Feb 1, 1968·The Journal of Experimental Medicine·C G Cochrane, H J Müller-Eberhard
Oct 1, 1975·Journal of Oral Pathology·J E Volanakis
Mar 5, 2016·Frontiers in Immunology·Ana Catarina Lunz Macedo, Lourdes Isaac
Sep 1, 1989·Circulation Research·U del BalzoR Levi
Jul 1, 1963·The Journal of Experimental Zoology·P J VANALTEN, A M SCHECHTMAN
Jan 2, 2018·The Open Rheumatology Journal·Vaneet Sandhu, Michele Quan
Jan 1, 1967·Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie·W Vogt
Feb 13, 2018·Immunological Reviews·Frank A RedegeldUlrich Blank
Oct 1, 1969·Archives internationales de physiologie et de biochimie·J Lecomte
Feb 16, 1965·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·F HAHN, H GIERTZ
Apr 1, 1965·Klinische Wochenschrift·W RAAB, E KAISER

Related Concepts

Hemolytic Complement
Allergic Reaction

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.


Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.