Studies on the mechanism of reduced urinary osmolality after exposure of renal papilla

The Journal of Clinical Investigation
E L ChuangJ H Stein

Abstract

Studies were performed in Munich-Wistar rats to determine whether changes in papillary plasma flow might be responsible for the concentrating defect which occurs after exposure of the extrarenal papilla. Papillary plasma flow was measured by (125)I-albumin accumulation. Initial studies in hydropenic animals revealed that papillary plasma flow was 40% higher in the kidney with the exposured papilla, 41 vs. 29 ml/min per 100 g of papilla (P < 0.001). This increase in papillary plasma flow was detectable 15 or 45 min after removing the ureter. Because it was unclear whether the rise in papillary plasma flow was a cause or the result of the fall in urine osmolality, similar studies were performed in animals undergoing a water diuresis. In this setting, papillary plasma flow still increased on the exposed side compared to the control side, 81 vs. 60 ml/min per 100 g, despite similarly low urine osmolalities of 155 and 174 mosmol/kg, respectively. This finding is compatible with the possibility that papillary exposure per se causes an increase in papillary plasma flow and that this hemodynamic alteration may lead to a reduction in urinary osmolality secondary to washout of the medullary interstitium. A final group of hydropenic rats ...Continue Reading

References

Jan 1, 1977·The Journal of Clinical Investigation·G M LumK M McDonald
Jul 1, 1974·Kidney International·K SolezR H Heptinstall
Jan 1, 1972·Pflügers Archiv : European journal of physiology·W Schütz, J Schnermann
Jul 25, 1974·Prostaglandins·K SolezR H Heptinstall
Nov 1, 1971·The Journal of Clinical Investigation·R L JamisonF Lacy
Jun 1, 1966·The Journal of Endocrinology·J Fourman, G C Kennedy
May 1, 1958·The American Journal of Medicine·R W BERLINERM EDEN
May 1, 1961·Circulation Research·L S LILIENFIELDM H BAUER
May 1, 1964·The American Journal of Medicine·C W GOTTSCHALK
May 1, 1964·The American Journal of Medicine·K THURAU

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Citations

Mar 1, 1979·The American Journal of Anatomy·E R Lacy, B Schmidt-Nielsen
Jun 1, 1982·Pflügers Archiv : European journal of physiology·D R Wilson, H Sonnenberg
Jun 15, 1984·Experientia·L N Reinking, M C Veale
Jan 1, 1985·Annals of Biomedical Engineering·R L JamisonC R Robertson
Jan 1, 1981·Progress in Lipid Research·L TobianJ Iwai
Oct 20, 2005·American Journal of Physiology. Renal Physiology·Mary Ella C PruittBodil Schmidt-Nielsen
Dec 1, 1978·The Journal of Clinical Investigation·J BuerkertS Klahr
Feb 1, 1979·The Journal of Clinical Investigation·J A HaasF G Knox
Jan 1, 1982·The Journal of Clinical Investigation·R E OliverR L Jamison
Mar 1, 1982·The Journal of Clinical Investigation·S Z FademJ H Stein
Apr 1, 1982·The Journal of Clinical Investigation·H J Reineck, R Parma
Nov 1, 1984·The Journal of Clinical Investigation·J BargmanR L Jamison
Aug 1, 1985·The Journal of Clinical Investigation·B ZimmerhacklR L Jamison
Feb 1, 1981·Archives internationales de physiologie et de biochimie·R VanholderS Ringoir
Jun 1, 1981·Kidney International·P A GrossR J Anderson
Feb 1, 1987·Kidney International·B Schmidt-Nielsen
Feb 1, 1987·Kidney International·B L ZimmerhacklR L Jamison
Jan 1, 1990·Kidney International·S Y ChouP F Faubert
Apr 1, 1985·Kidney International·L SternJ P Hayslett
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·S Randall Thomas
Feb 1, 1982·The American Journal of Medicine·R L Jamison, R E Oliver
Jan 17, 1986·The American Journal of Medicine·K H Raymond, M D Lifschitz
Nov 1, 1985·Circulation Research·B ZimmerhacklR L Jamison
Sep 1, 1983·Circulation Research·C HolligerR L Jamison
Dec 1, 1982·Circulation Research·S SpitalewitzJ G Porush
Sep 1, 1991·The Anatomical Record·N S Maluf
Jan 1, 1985·Critical Reviews in Toxicology·P H Bach, J W Bridges
Jan 1, 1985·CRC Critical Reviews in Toxicology·P H Bach, J W Bridges
Apr 5, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas L PalloneRex L Jamison
Jan 31, 2003·American Journal of Physiology. Renal Physiology·Mark A KnepperTerry Dwyer
Feb 9, 2000·American Journal of Physiology. Renal Physiology·A EdwardsT L Pallone
Jul 18, 2019·American Journal of Physiology. Renal Physiology·Anita T Layton
Oct 29, 1982·Biochemical and Biophysical Research Communications·A R MorrisonW A Brown
Apr 1, 1982·Kidney International·R J AndersonP A Gross

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