PMID: 233Jan 1, 1976

Studies on the mechanism of the changes in serum and liver gamma-glutamyl transpeptidase activity. II. Experimental hexachlorobenzene porphyria in rabbits

Enzyme
E IvanovV Pramatarova

Abstract

The mechanism responsible for the changes in serum and liver gamma-glutamyl transpeptidase (gamma-GT) activity was studied in a model of experimental hexachlorobenzene porphyria in rabbits. Porphyria followed the administration of hexachlorobenzene in doses of 280 mumol - kg-1 body weight, which were given daily through a gastric tube over a 20-day period. Serum gamma-GT activity and the activities of the lysosomal enzymes beta-N-acetylglucosaminidase and alpha-mannosidase were increased, whereas L-aspartate: 2-oxoglutarate aminotransferase and L-alanine: 2-oxoglutarate aminotransferase and L-alanine: 2-oxoglutarate aminotransferase remained unaltered. There was a considerable increase in liver microsomal protein, gamma-GT, cytochrome P-450, anilinehydroxylase, aminopyrine-demethylase and delta-aminolevulinic acid synthase. In the liver gamma-GT was detected in the microsomes as well as in the cytoplasm where enzymatic activity was higher. The high correlation coefficient between liver gamma-GT, cytochrome P-450 and delta-aminolevulinic acid synthase witnesses a hexachlorobenzene-induced gamma-GT formation in the liver. A statistically significant correlation between serum and liver gamma-GT activity was also found. These data ...Continue Reading

Citations

Jan 1, 1980·CRC Critical Reviews in Clinical Laboratory Sciences·D M Goldberg
Sep 21, 2001·Critical Reviews in Clinical Laboratory Sciences·J B Whitfield

Related Concepts

Beta-N-Acetylglucosaminidase
Metazoa
Gamma-glutamyl transferase
Hexachlorobenzene
Liver
Mannosidase
Disorders of Porphyrin Metabolism
Porphyrins
Chinchilla Rabbits

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