PMID: 6165358Dec 15, 1980Paper

Studies on the mechanisms of biliary excretion of circulating glycoproteins. The carcinoembryonic antigen

The Biochemical Journal
P Thomas

Abstract

The transport of carcinoembryonic antigen from the circulation of the bile has been studied in the rat. Biliary excretion was directly proportional to the intravenously administered dose. Approximately 1-1.5% of the injected is excreted in the bile. Asialo-(carcinoembryonic antigen), asialo-fetuin and asialo-(alpha 1-acid glycoprotein) behaved similarly. The transit time through the liver for both native- and asialo-(carcinoembryonic antigen) was calculated as 47 min. Sialic acid content was not affected during biliary excretion. Glycoproteins that entered the liver cell lysosomes were not excreted in ther bile. A mechanism by which circulating proteins may by-pass the hepatocytes before being excreted in bile is suggested. Alternative mechanisms of protein entry into bile are discussed.

Citations

Sep 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M S KressnerI Sternlieb
Mar 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N Kono, Y Nakanuma
Jun 8, 2001·São Paulo Medical Journal = Revista Paulista De Medicina·R M MouraL M Giuliano
Mar 1, 1983·Digestive Diseases and Sciences·P Thomas, N Zamcheck
Mar 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P ThomasN Zamcheck
Jan 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I Sternlieb, N Quintana
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W H Evans
Feb 1, 1982·Digestive Diseases and Sciences·P K GeorgeN Zamcheck
Sep 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A Reuben
Jan 1, 1985·The Journal of Communicable Diseases·B C Harinath
Nov 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P ThomasN Zamcheck
Jul 11, 2003·World Journal of Gastroenterology : WJG·Jaques WaisbergFabio S Goffi
Jan 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J R Lake, B F Scharschmidt
May 1, 1987·The American Journal of Physiology·M E TaylorJ A Summerfield
Dec 11, 1990·Biochimica Et Biophysica Acta·P ThomasG Steele

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